Epigenetics

by Allis, C. David; Jenuwein, Thomas; Reinberg, Danny; Caparros, Marie-Laure

• ISBN13: 9780879697242
• ISBN10: 0879697245
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-10-31
• Publisher: Cold Spring Harbor Laboratory Pr

Summary

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

Table of Contents

Preface	ix
Epigenetics: From Phenomenon to Field	1	(14)
Daniel E. Gottschling
A Brief History of Epigenetics	15	(8)
Gary Felsenfeld
Overview and Concepts	23	(40)
C. David Allis
Thomas Jenuwein
Danny Reinberg
Epigenetics in Saccharomyces cerevisiae	63	(18)
Michael Grunstein
Susan M. Gasser
Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila	81	(20)
Sarah C.R. Elgin
Gunter Reuter
Fungal Models for Epigenetic Research: Schizosac-charomyces pombe and Neurospora crassa	101	(26)
Robin C. Allshire
Eric U. Selker
Epigenetics of Ciliates	127	(24)
Eric Meyer
Douglas L. Chalker
RNAi and Heterochromatin Assembly	151	(16)
Robert Martienssen
Danesh Moazed
Epigenetic Regulation in Plants	167	(24)
Marjori Matzke
Ortrun Mittelsten Scheid
Chromatin Modifications and Their Mechanism of Action	191	(20)
Tony Kouzarides
Shelley L. Berger
Transcriptional Silencing by Polycomb Group Proteins	211	(20)
Ueli Grossniklaus
Renato Paro
Transcriptional Regulation by Trithorax Group Proteins	231	(18)
Robert E. Kingston
John W. Tamkun
Histone Variants and Epigenetics	249	(16)
Steven Henikoff
M. Mitchell Smith
Epigenetic Regulation of Chromosome Inheritance	265	(26)
Gary H. Karpen
R. Scott Hawley
Epigenetic Regulation of the X Chromosomes in C. elegans	291	(16)
Susan Strome
William G. Kelly
Dosage Compensation in Drosophila	307	(14)
John C. Lucchesi
Mitzi I. Kuroda
Dosage Compensation in Mammals	321	(20)
Neil Brockdorff
Bryan M. Turner
DNA Methylation in Mammals	341	(16)
En Li
Adrian Bird
Genomic Imprinting in Mammals	357	(20)
Denise P. Barlow
Marisa S. Bartolomei
Germ Line and Pluripotent Stem Cells	377	(20)
M. Azim Surani
Wolf Reik
Epigenetic Control of Lymphopoiesis	397	(18)
Meinrad Busslinger
Alexander Tarakhovsky
Nuclear Transplantation and the Reprogramming of the Genome	415	(20)
Rudolf Jaenisch
John Gurdon
Epigenetics and Human Disease	435	(22)
Huda Y. Zoghbi
Arthur L. Beaudet
Epigenetic Determinants of Cancer	457	(34)
Stephen B. Baylin
Peter A. Jones
Appendices
WWW Resources	477	(2)
Histone Modifications and References	479	(12)
Index	491