Epigenetics

Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs and parts that did not pre-exist in the fertilized egg. An exciting and stimulating volume which used the extensive knowledge of basic transcriptional control as a foundation to explore the more complex and interesting level at which genes can be regulated.

Symposium on Epigenetics, held at the Novartis Foundation on 24-26 June 1997 This symposium is based on a proposal made by Alan P. Wolffe

Derek J. Chadwick (Organizer)

Gail Cardew

A. P. Wolffe

Introduction

1

(5)

X. Nan

S. Cross

A. Bird

Gene silencing by methyl-CpG-binding proteins

6

(16)

Discussion

16

(6)

S.U. Kass

A. P. Wolffe

DNA methylation, nucleosomes and the inheritance of chromatin structure and function

22

(29)

Discussion

35

(11)

General discussion I The methylation of CpG islands

46

(5)

R. Paro

H. Strutt

G. Cavalli

Heritable chromatin states induced by the Polycomb and trithorax group genes

51

(16)

Discussion

61

(6)

F. Grosveld

E. de Boer

N. Dillon

J. Gribnau

T. McMorrow

E. Milot

T. Trimborn

M. Wijgerde

P. Fraser

The dynamics of globin gene expression and position effects

67

(20)

Discussion

79

(8)

A.J.S. Klar

A. V. Ivanova

J. Z. Dalgaard

M. J. Bonaduce

S.I.S. Grewal

Multiple epigenetic events regulate mating-type switching of fission yeast

87

(27)

Discussion

99

(5)

General discussion II Centromeres

104

(10)

S.M. Gasser

M. Gotta

H. Renauld

T. Laroche

M. Cockell

Nuclear organization and silencing: trafficking of Sir proteins

114

(19)

Discussion

126

(7)

R. Raina

M. Schlappi

N. Fedoroff

Epigenetic mechanisms in the regulation of the maize Suppressor mutator transposon

133

(11)

Discussion

140

(4)

R.B. Flavell

M. O'Dell

M. Metzlaff

Transgene-promoted epigenetic switches of chalcone synthase activity in petunia plants

144

(24)

Discussion

154

(9)

General discussion III Nucleolar organization

163

(1)

The silencing of endogenous sequences and transgenes

164

(4)

M.A. Matzke

A.J.M. Matzke

Gene silencing in plants: relevance for genome evolution and the acquisition of genomic methylation patterns

168

(19)

Discussion

181

(6)

T.H. Bestor

The host defence function of genomic methylation patterns

187

(13)

Discussion

195

(5)

R. Jaenisch

C. Beard

J. Lee

Y. Marahrens

B. Panning

Mammalian X chromosome inactivation

200

(14)

Discussion

209

(5)

A.D. Riggs

Z. Xiong

L. Wang

J.M. LeBon

Methylation dynamics, epigenetic fidelity and X chromosome structure

214

(19)

Discussion

225

(3)

General discussion IV Does DNA methylation regulate gene activity?

228

(5)

J.D. Brenton

J.F.-X. Ainscough

F. Lyko

R. Paro

M.A. Surani

Imprinting and gene silencing in mice and Drosophila

233

(18)

Discussion

244

(7)

A. Wutz

O.W. Smrzka

D.P. Barlow

Making sense of imprinting the mouse and human IGF2R loci

251

(13)

Discussion

260

(4)

U. Francke

Imprinted genes in the Prader Willi deletion

264

(16)

Discussion

275

(5)

Final general discussion Rules of DNA methylation in humans inferred from the fragile X gene, FMR1

280

(11)

A.P. Wolffe

Summary

291

(2)

Index of contributors

293

(2)

Subject index

295

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