Erythropoietins and Erythropoiesis

by Molineux, Graham; Foote, Maryann; Elliott, Steven G.; Elliott, Steven G.

• ISBN13: 9783764369194
• ISBN10: 3764369191
• Format: Hardcover
• Copyright: 2003-09-01
• Publisher: Birkhauser

Summary

This volume is a one-source guide to the most current information about red blood cell formation and the action of recombinant human erythropoietins. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia will be covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. It is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators.

Table of Contents

List of contributors	VII
Preface	IX
I. Background and basic science
Lyonel G. Israels and Esther D. Israels
Erythropoiesis: an overview	3	(12)
MaryAnn Foote
Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin	15	(10)
Timothy Osslund and Rashid Syed
Structural basis for the signal transduction of erythropoietin	25	(10)
Christof Dame
Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues	35	(30)
Saghi Ghaffari, Lily Jun-shen Huang, Jing Zhang, and Harvey F. Lodish
Erythropoietin receptor signaling processes	65	(22)
Anne C. Heatherington
Clinical pharmacokinetic properties of rHuEPO: a review	87	(26)
Graham Molineux
Biology of erythropoietin	113	(20)
Alice S. Chuck, Rohini R. Deshpande, Adrian R. Distler, Shane A. Sander, and James E. Seely
Commercial production of recombinant erythropoietins	133	(20)
II. Clinical use of recombinant erythropoietins
Iain C. Macdougall
Use of recombinant erythropoietins in the setting of renal disease	153	(10)
John Glaspy
Erythropoietic therapy in the practice of oncology	163	(22)
Robert T. Means, Jr.
Use of recombinant erythropoietins for the treatment of anemia of chronic disease	185	(12)
Fred D. Cushner
Use of erythropoietins in the surgical setting	197	(8)
Don H. Catlin, Caroline K. Hatton, and Françoise Lasne
Abuse of recombinant erythropoietins by athletes	205	(24)
Patrick Mayeux and Nicole Casadevall
Antibodies to endogenous and recombinant erythropoietin	229	(12)
Steven G. Elliott
New molecules and formulations of recombinant human erythropoietin	241	(18)
Glossary and abbreviations	259	(4)
Index	263