What is included with this book?
Contributors | p. ix |
Statistical Methods and Challenges in Epidemiology and Biomedical Research | p. 1 |
Introduction | p. 1 |
Characterizing the study cohort | p. 3 |
Observational study methods and challenges | p. 6 |
Randomized controlled trials | p. 12 |
Intermediate, surrogate, and auxiliary outcomes | p. 17 |
Multiple testing issues and high-dimensional biomarkers | p. 18 |
Further discussion and the Women's Health Initiative example | p. 20 |
References | p. 22 |
Statistical Methods for Assessing Biomarkers and Analyzing Biomarker Data | p. 27 |
Introduction | p. 27 |
Statistical methods for assessing biomarkers | p. 28 |
Statistical methods for analyzing biomarker data | p. 44 |
Concluding remarks | p. 61 |
References | p. 61 |
Linear and Non-Linear Regression Methods in Epidemiology and Biostatistics | p. 66 |
Introduction | p. 66 |
Linear models | p. 69 |
Non-linear models | p. 84 |
Special topics | p. 93 |
References | p. 99 |
Count Response Regression Models | p. 104 |
Introduction | p. 104 |
The Poisson regression model | p. 106 |
Heterogeneity and overdispersion | p. 118 |
Important extensions of the models for counts | p. 123 |
Software | p. 142 |
Summary and conclusions | p. 144 |
References | p. 144 |
Mixed Models | p. 146 |
Introduction | p. 146 |
Estimation for the linear mixed model | p. 152 |
Inference for the mixed model | p. 154 |
Selecting the best mixed model | p. 157 |
Diagnostics for the mixed model | p. 161 |
Outliers | p. 163 |
Missing data | p. 163 |
Power and sample size | p. 164 |
Generalized linear mixed models | p. 165 |
Nonlinear mixed models | p. 167 |
Mixed models for survival data | p. 168 |
Software | p. 168 |
Conclusions | p. 169 |
References | p. 170 |
Factor Analysis and Related Methods | p. 174 |
Introduction | p. 174 |
Exploratory factor analysis (EFA) | p. 175 |
Principle components analysis (PCA) | p. 182 |
Confirmatory factor analysis (CFA) | p. 182 |
FA with non-normal continuous variables | p. 186 |
FA with categorical variables | p. 187 |
Sample size in FA | p. 189 |
Examples of EFA and CFA | p. 190 |
Additional resources | p. 196 |
Appendix A | p. 198 |
Appendix B | p. 198 |
References | p. 198 |
Structural Equation Modeling | p. 202 |
Models and identification | p. 202 |
Estimation and evaluation | p. 206 |
Extensions of SEM | p. 217 |
Some practical issues | p. 221 |
References | p. 224 |
Statistical Modeling in Biomedical Research: Longitudinal Data Analysis | p. 235 |
Introduction | p. 235 |
Analysis of longitudinal data | p. 237 |
Design issues of a longitudinal study | p. 261 |
References | p. 266 |
Sequential and Group Sequential Designs in Clinical Trials: Guidelines for Practitioners | p. 269 |
Introduction | p. 270 |
Historical background of sequential procedures | p. 271 |
Group sequential procedures for randomized trials | p. 272 |
Steps for GSD design and analysis | p. 284 |
Discussion | p. 285 |
References | p. 287 |
Estimation of Marginal Regression Models with Multiple Source Predictors | p. 291 |
Introduction | p. 291 |
Review of the generalized estimating equations approach | p. 293 |
Maximum likelihood estimation | p. 296 |
Simulations | p. 298 |
Efficiency calculations | p. 301 |
Illustration | p. 302 |
Conclusion | p. 304 |
References | p. 306 |
The Bayesian Approach to Experimental Data Analysis | p. 308 |
Preamble: and if you were a Bayesian without knowing it? | p. 308 |
Introduction | p. 309 |
Frequentist and Bayesian inference | p. 311 |
An illustrative example | p. 316 |
Other examples of inferences about proportions | p. 328 |
Concluding remarks and some further topics | p. 335 |
References | p. 341 |
Subject Index | p. 345 |
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