Essentials of Apoptosis

by Yin, Xiao-Ming; Dong, Zheng

• ISBN13: 9781603273800
• ISBN10: 1603273808
• Edition: 2nd
• Format: Hardcover
• Copyright: 2009-06-20
• Publisher: Humana Pr Inc

Summary

This is the second edition of the comprehensive, concise summary of apoptosis research. It covers the major concepts, molecular architecture, the biochemical pathways, and pathophysiological significance of apoptosis. This book provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration. Since the original publication in 2003, the apoptosis field has expanded rapidly ' chapters not only need to be revised and expanded, but there is a need for all new chapters covering exciting advances in bioinformatics, systems biology, oxidative stress, etc.

Table of Contents

Molecules and Pathways of Apoptosis
Caspases: Activation, Regulation, and Function	p. 3
The Bcl-2 Family Proteins	p. 25
The Mammalian IAPs: Multifaceted Inhibitors of Apoptosis	p. 63
Structural Biology of Programmed Cell Death	p. 95
The Death Receptor Pathway	p. 119
The Mitochondrial Pathway: Focus on Shape Changes	p. 151
The Endoplasmic Reticulum Pathway	p. 177
Reactive Oxygen Species in Cell Fate Decisions	p. 199
The Integration of Metabolism and Cell Death	p. 223
Transcriptional Regulation of Apoptosis	p. 239
Clearance of Apoptotic Cells - Mechanisms and Consequences	p. 261
Systems Biology Approaches to the Study of Apoptosis	p. 283
Apoptosis in Model Organisms
Programmed Cell Death in Plants: Apoptotic but Not Quite	p. 301
Tracing the Roots of Death: Apoptosis in Saccharomyces cerevisiae	p. 325
Programmed Cell Death in C. elegans	p. 355
Cell Death in Drosophila	p. 375
Apoptosis in Mammalian Physiology and Pathogenesis
Cell Death: Defining and Misshaping Mammalian Embryos	p. 409
Matters of Life and Death in the Immune System	p. 423
Cell Death in the Hematopoietic System	p. 443
Cell Death in Acute Neuronal Injury	p. 461
Apoptosis in Neurodegenerative Diseases	p. 479
Apoptosis in Cardiovascular Pathogenesis	p. 505
Apoptosis in Lung Injury and Disease	p. 523
Apoptosis in Liver Injury and Liver Diseases	p. 547
Apoptosis in Acute Kidney Injury	p. 565
Apoptosis in Cancer Biology and Cancer Therapeutics	p. 581
Alternative Cell Death Mechanisms and Pathways
Necrosis: Molecular Mechanisms and Physiological Roles	p. 599
Caspase-Independent Mitotic Death	p. 635
Lysosomal Proteases in Cell Death	p. 647
Autophagy and Cell Death	p. 671
Approaches to the Study of Apoptosis
Analysis of Apoptosis: Basic Principles and Protocols	p. 691
Index	p. 713
Table of Contents provided by Ingram. All Rights Reserved.