Essentials of Apoptosis : A Guide for Basic and Clinical Research

by Yin, Xiao-Ming

• ISBN13: 9781588291462
• ISBN10: 1588291464
• Format: Hardcover
• Copyright: 2003-03-01
• Publisher: Springer Verlag

Summary

Basic and clinical investigators systematically compile a comprehensive but concise summary of essential, up-to-date information about apoptosis. The authors present the concepts, the molecular architecture, the biochemical pathways, and the pathophysiological significance of apoptosis. In addition, standard biochemical and cell biologic approaches to apoptosis research are described as a guideline for bench work, with clinical applications detailed for immune disorders, cancer, ischemia/reperfusion injury, and neuronal degeneration.

Table of Contents

Preface	v
Contributors	ix
PART 1: MOLECULES AND PATHWAYS OF APOPTOSIS
1 Caspases: Structure, Activation Pathways, and Substrates	3	(26)
Brona M. Murphy and Seamus J. Martin	13	(16)
2 Bcl-2 Family Proteins: Master Regulators of Apoptosis
Xiao-Ming Yin, Wen-Xing Ding, and Yongge Zhao
3 Inhibitors of Apoptosis Proteins	29	(18)
Peter Liston, Wai Gin Fong, and Robert G. Korneluk
4 Structural Biology of Programmed Cell Death	47	(20)
Yigong Shi
5 The Death Receptor Family and the Extrinsic Pathway	67	(18)
Maria Eugenia Guicciardi and Gregory J. Gores
6 The Mitochondrial Apoptosis Pathway	85	(16)
Bruno Antonsson
7 From Caspases to Alternative Cell-Death Mechanisms	101	(24)
Marja Jaattela and Marcel Leist
PART 2: APOPTOSIS IN ACTION
8 Apoptosis in Plants, Yeast, and Bacteria	125	(10)
Ron Mittler and Vladimir Shulaev
9 Programmed Cell Death in C. elegans	135	(10)
Yi-Chun Wu and Ding Xue
10 Cell Death in Drosophila	145	(18)
Sujin Bao and Ross L. Cagan
11 Cell Death in Mammalian Development	163	(14)
Chia-Yi Kuan and Keisuke Kuida
12 Apoptosis and Cancer: Pathogenic and Therapeutic Implications	177	(24)
Sean L. O'Connor, Fermin Briones, Nikhil S. Chari, Song H. Cho,
Rebecca L. Hamm, Yoshihiko Kadowaki, Sangjun Lee, Kevin B. Spurgers,
and Timothy J. McDonnell
13 Cell Death in Immune, Inflammatory, and Stress Responses	201	(10)
J. John Cohen, Maria D. Devore, Mile Cikara, and Elizabeth A. Dowling
14 Cell-Death Mechanisms in Neurodegenerative Diseases: Diversity
Among Cerebral Ischemia, Parkinson's Disease, and Huntington's Disease	211	(14)
R. Anne Stetler and Jun Chen
15 Apoptosis in Ischemic Disease	225	(14)
Zheng Dong and Manjeri A. Venkatachalam
PART III: APPROACHES TO THE STUDY OF APOPTOSIS
16 Analysis of Apoptosis: Basic Principles and Procedures	239	(14)
Li Bai, Jinzhao Wang, Xiao-Ming Yin, and Zheng Dong
Index	253