Essentials of Glycobiology

by Varki, Ajit; Cummings, Richard; Esko, Jeffrey; Freeze, Hudson; Hart, Gerald; Marth, Jamey

• ISBN13: 9780879695606
• ISBN10: 0879695609
• Format: Hardcover
• Copyright: 1999-08-01
• Publisher: Cold Spring Harbor Laboratory Pr

Summary

Univ. of California - San Diego, La Jolla. Intro- ductory textbook to the field of glycobiology. Contains basic information and is based on the 1998 UCSD Spring Quarter Graduate Course in Glycobiology. Color and halftone illustrations. Extensive references. For graduate students. Printed hardcover (student version), cloth library version also available.

Table of Contents

Foreword	vii
Preface	ix
Contributors	xiii
Abbreviations	xv
GENERAL PRINCIPLES
Historical Background and Overview	1	(16)
Saccharide Structure and Nomenclature	17	(14)
Evolution of Glycan Diversity	31	(10)
Protein-Glycan Interactions	41	(16)
Exploring the Biological Roles of Glycans	57	(12)
BIOSYNTHESIS, METABOLISM, AND FUNCTION
Monosaccharide Metabolism	69	(16)
N-Glycans	85	(16)
O-Glycans	101	(14)
Glycosphingolipids	115	(16)
Glycophospholipid Anchors	131	(14)
Proteoglycans and Glycosaminoglycans	145	(16)
Other Classes of Golgi-derived Glycans	161	(10)
Nuclear and Cytoplasmic Glycosylation	171	(12)
The O-GlcNAc Modification	183	(12)
Sialic Acids	195	(16)
Structures Common to Different Types of Glycans	211	(42)
Glycosyltransferases	253	(14)
Degradation and Turnover of Glycans	267	(18)
Glycosylation in ``Model'' Organisms	285	(20)
Glycobiology of Plant Cells	305	(16)
Bacterial Polysaccharides	321	(12)
PROTEINS THAT RECOGNIZE GLYCANS
Discovery and Classification of Animal Lectins	333	(12)
P-type Lectins	345	(18)
I-type Lectins	363	(16)
C-type Lectins	379	(12)
Selectins	391	(26)
S-type Lectins (Galectins)	417	(12)
Microbial Glycan-binding Proteins	429	(12)
Glycosaminoglycan-binding Proteins	441	(14)
Plant Lectins	455	(14)
GLYCANS IN GENETIC DISORDERS AND DISEASE
Genetic Disorders of Glycosylation in Cultured Cells	469	(10)
Naturally Occurring Genetic Disorders of Glycosylation	479	(20)
Determining Glycan Function Using Genetically Modified Mice	499	(16)
Glycosylation Changes in Ontogeny and Cell Activation	515	(22)
Glycosylation Changes in Cancer	537	(14)
Glycobiology of Protozoal and Helminthic Parasites	551	(14)
Acquired Glycosylation Changes in Human Disease	565	(16)
METHODS AND APPLICATIONS
Structural Analysis and Sequencing of Glycans	581	(18)
Chemical and Enzymatic Synthesis of Glycans	599	(10)
Natural and Synthetic Inhibitors of Glycosylation	609	(16)
Glycobiology in Biotechnology and Medicine	625	(10)
Glossary: Commonly Used Terms	635	(6)
Index	641