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This new third edition, written by the world’s leading cardiologists, provides graded evidence-based reviews of the major trials together with recommendations for optimum management, and now includes new grading and recommendation methodology.
This is a unique book in the field of cardiology, and the largest evidence based clinical cardiology text.
John Cairns Dean, Faculty of Medicine, University of British Columbia.
John Camm, Professor of Clinical Cardiology and Head of the Department of Cardiac & Vascular Sciences at St George's, University of London.
Ernest Fallen, Professor Emeritus in Cardiology and Tutor in Cardiology Residency Program, McMaster University, Hamilton, Ontario.
Bernard Gersh, Professor of Medicine, Department of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota.
Preface to the third edition, xiv
Classification of recommendations and levels of evidence, xvi
List of abbreviations, xvii
Part I: General concepts and critical appraisalSalim Yusuf, Editor
1 Evidence-based decision making: patient–physician interface, 3Philip J Devereaux, Marc Pfeffer, Salim Yusuf
2 Obtaining incremental information from diagnostic tests, 14Raymond J Gibbons
3 Clinical trials and meta-analysis, 26Jonathan R Emberson, Colin Baigent
4 Understanding concepts related to health economics, 38Mark A Hlatky
5 Major vascular complications in patients undergoing non-cardiac surgery: magnitude of the problem, risk prediction, surveillance, and prevention, 47Philip J Devereaux, Matthew Chan, John Eikelboom
6 Implementing evidence-based medicine in cardiology, 63Brahmajee K Nallamothu, Thomas T Tsai, Jack V Tu
7 The application of evidence-based medicine to employment fitness standards: the transportation industries with special reference to aviation, 79Michael Joy
Part II: Prevention of cardiovascular diseasesSalim Yusuf and John A Cairns, Editors
8 Global perspective on cardiovascular disease, 95K Srinath Reddy
9 Avoidance of worldwide vascular deaths and total deaths from smoking, 111Prabhat Jha, Prem Mony, James Moore, Witold Zatonski
10 Tobacco and cardiovascular disease: achieving smoking cessation in cardiac patients, 125Andrew Pipe
11 Lipids and cardiovascular disease, 138Malcolm Law
12 Use of lipid-lowering agents in the prevention of cardiovascular disease, 147R Alan Failor, Jeffrey L Probstfi eld
13 Blood pressure and cardiovascular disease, 165Curt D Furberg, Bruce M Psaty, Elsayed Z Soliman
14 Dysglycemia and the risk of cardiovascular events, 179Hertzel C Gerstein, Zubin Punthakee
15 Physical activity and exercise in cardiovascular disease prevention and rehabilitation, 190Ray W Squires
16 Psychosocial factors, 201Annika Rosengren
17 The social determinants of cardiovascular disease, 211Martin McKee, Clara K Chow
18 Obesity, 221Raj S Padwal, Arya M Sharma
19 Ethnicity and cardiovascular disease, 235Clara K Chow, Sonia S Anand, Salim Yusuf
20 Fetal origins of coronary artery disease, 258Katherine M Morrison, Stephanie Atkinson, Koon K Teo
21 Genetics of coronary heart disease, 268Michael S Cunnington, Bernard D Keavney
22 Molecular genetics of cardiovascular disorders, 288Ali J Marian, Robert Roberts
23 Diet and cardiovascular disease, 304K Srinath Reddy
24 Integrating approaches to prevention of cardiovascular disease, 328David A Wood, Kornelia Kotseva
Part IIIa: Stable coronary artery diseaseJohn A Cairns and Bernard J Gersh, Editors
25 Medical management of stable coronary artery disease, 345William E Boden
26 Percutaneous intervention, 357David A Wood, Rohit Khurana, Christopher E Buller
27 Surgical coronary artery revascularization, 379Morgan L Brown, Thoralf M Sundt III
28 Comparisons of percutaneous coronary intervention and coronary artery bypass grafting, 392Arashk Motiei, Thoralf M Sundt III, Charanjit S Rihal
Part IIIb: Acute coronary syndromesJohn A Cairns and Bernard J Gersh, Editors
29 Non-ST segment elevation acute coronary syndromes: unstable angina and non-ST segment elevation myocardial infarction, 409Pierre Theroux, John A Cairns
30 Early prehospital management of ST segment elevation myocardial infarction, 444Robert C Welsh, Paul W Armstrong
31 Reperfusion therapies for ST segment elevation myocardial infarction, 456Joseph B Muhlestein, Jeffrey L Anderson
32 Antithrombotic therapies for patients with ST segment elevation myocardial infarction, 475Andrew J Lucking, Keith A A Fox
33 Complications after myocardial infarction, 495Peter L Thompson
34 An integrated approach to the management of patients after the early phase of ST segment elevation myocardial infarction, 516Pedro L Sánchez, Francisco Fernández- Avilés
Part IIIc: ArrhythmiasA John Camm and John A Cairns, Editors
35 Atrial fibrillation: rhythm and rate control therapies, 531Irina Savelieva, Albert L Waldo, A John Camm
36 Atrial fi brillation: upstream therapies, 568Antonios Kourliouros, Irina Savelieva, Marjan Jahangiri, A John Camm
37 Atrial fibrillation: antithrombotic therapy, 581John A Cairns, Stuart Connolly
38 Ablation therapy for atrial fi brillation, 596Conor D Barrett, Chi Keong Ching, Luigi Di Biase, Claude S Elayi, David J Burkhardt, Rodney Horton, Andrea Natale
39 Supraventricular tachycardia, 606Erica D Penny-Peterson, Gerald V Naccarelli
40 Prevention and treatment of life-threatening ventricular arrhythmia and sudden death, 619Carlos A Morillo, Adrian Baranchuk
41 Pacemaker therapy, including cardiac resynchronization therapy, 636William D Toff, A John Camm
42 Syncope, 673David G Benditt, Fei Lu, Scott Sakaguchi
43 Cardiopulmonary resuscitation, 692Michael Colquhoun
44 Arrhythmias due to monogenic disorders, 706Dawood Darbar, Prince Kannankeril, Dan M L Roden
45 Arrhythmiagenic right ventricular cardiomyopathy, 721Deirdre Ward, Perry M Elliott
Part IIId: Specifi c cardiovascular disorders: left ventricular dysfunctionSalim Yusuf, Editor
46 Epidemiology and prevention of heart failure and management of asymptomatic left ventricular systolic dysfunction, 735J Paul Rocchiccioli, John J V McMurray
47 Management of overt heart failure, 756Paul J Hauptman, Karl Swedberg
48 Acute myocarditis and dilated cardiomyopathy, 784Leslie T Cooper Jr, Oyere K Onuma
49 Management of hypertrophic cardiomyopathy, 796Barry J Maron
50 Infective and infi ltrative cardiomyopathies, 808Stavros Kounas, Perry M Elliott
51 Chagas’ heart disease, 823J Antonio Marin-Neto, Anis Rassi Jr, Benedito Carlos Maciel, Marcus Vinicius Simões, André Schmidt
Part IIIe: Specifi c cardiovascular disorders: pericardial diseaseBernard J Gersh, Editor
52 Pericardial disease: an evidence-based approach to clinical management, 845Faisal F Syed, Bongani M Mayosi
Part IIIf: Specifi c cardiovascular disorders: valvular heart diseaseBernard J Gersh, Editor
53 Rheumatic heart disease: prevention and acute treatment, 861Bongani M Mayosi, Patrick J Commerford
54 Mitral valve disease: indications for surgery, 869Blase A Carabello
55 Surgical indications in aortic valve disease, 878Sunil Mankad, Heidi M Connolly, Shahbudin H Rahimtoola
56 Non-surgical aortic valve therapy: balloon valvuloplasty and transcatheter aortic valve replacement, 896Robert H Boone, John G Webb
57 Balloon valvuloplasty: mitral valve, 913Zoltan G Turi
58 Valve repair and choice of valve, 927Shafie S Fazel, Tirone E David
59 Infective endocarditis, 941Zainab Samad, Andrew Wang
60 Antithrombotic therapy after heart valve replacement, 957Jack C J Sun, John W Eikelboom
Part IIIg: Specifi c cardiovascular disorders: other conditionsBernard J Gersh and Salim Yusuf, Editors
61 Stroke, 971Brian H Buck, Ashfaq Shuaib, Craig Anderson
62 Heart disease and pregnancy, 993Rachel M Wald, Samuel C Siu
63 Adult congenital heart disease, 1006Elisabeth Bédard, Michael A Gatzoulis
64 Venous thromboembolic disease, 1032Lori-Ann Linkins, Clive Kearon
65 Peripheral arterial disease, 1050Catherine McGorrian, Sonia S Anand
66 Cardiac risk in those undergoing non-cardiac surgery, 1068Ameeth Vedre, Kim A Eagle
67 Clinical management of diseases of the aorta, 1079Thoralf M Sundt III
68 Cardiac transplantation: indications and postoperative management, 1099Barry Boilson, Sudhir Kushwaha
69 Renal dysfunction, 1110Johannes F E Mann, Ernesto L Schiffrin
70 Pulmonary hypertension, 1118Brendan P Madden
Part IV: Clinical applicationsErnest L Fallen, Editor
71 Clinical applications of external evidence, 1135Ernest L Fallen, Salim Yusuf
72 Stable angina: choice of PCI versus CABG versus drugs, 1138William S Weintraub
73 Non-ST segment acute coronary syndrome, 1142David Fitchett
74 Acute ST segment elevation myocardial infarction, 1152Ernest L Fallen
75 Secondary prevention strategies post myocardial infarction, 1157Jacques Genest
76 Heart failure, 1164Michael M Givertz, Garrick C Stewart
77 Atrial fibrillation, 1170Michael Klein
78 The case for and against implantable cardioverter defibrillators in patients with coronary artery disease, 1174Jeffrey S Healey
79 Bradyarrhythmias – choice of pacemakers, 1178Pablo B Nery, Carlos A Morillo
80 Peripheral arterial disease with suspect coronary artery disease, 1183Victor Aboyans, Michael H Criqui
81 Valvular heart disease: timing of surgery, 1187Jon-David R Schwalm, Victor Chu
Index, 1191
The colour plate section can be found facing p. 941
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