Evidence-Based Diagnosis

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2009-02-16
  • Publisher: Cambridge University Press
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Supplemental Materials

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Evidence-Based Diagnosis is a textbook about diagnostic, screening, and prognostic tests in clinical medicine. The authors' approach is based on many years of experience teaching physicians in a clinical research training program. Although requiring only a minimum of mathematics knowledge, the quantitative discussions in this book are deeper and more rigorous than in most introductory texts. The book includes numerous worked examples and 60 problems (with answers) based on real clinical situations and journal articles. The book will be helpful and accessible to anyone looking to select, develop, or market medical tests. Topics covered include: -The diagnostic process -Test reliability and accuracy -Testing and treatment thresholds -Critical appraisal of studies of diagnostic, screening and prognostic tests -Test independence and methods of combining tests -Quantifying treatment benefits using randomized trials and observational studies -Bayesian interpretation of P values and confidence intervals -Challenges for evidence-based diagnosis -Likelihood ratios -ROC curves

Table of Contents

Introduction: understanding diagnosis and diagnostic testing
Reliability and measurement error
Dichotomous tests
Multilevel and continuous tests
Critical appraisal of studies of diagnostic tests
Screening tests
Prognostic tests and studies
Multiple tests and multivariable decision rules
Quantifying treatment effects using randomized trials
Alternatives to randomized trials for estimating treatment effects
Understanding P-values and confidence intervals
Challenges for evidence-based diagnosis
Table of Contents provided by Publisher. All Rights Reserved.

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