Evolutionary Biology of Aging

by Rose, Michael R.

• ISBN13: 9780195061338
• ISBN10: 0195061330
• Format: Hardcover
• Copyright: 1990-11-15
• Publisher: Oxford University Press

Summary

This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerfuldetermining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues forseeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support thecentral thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.

Table of Contents

The Evolutionary Theory of Aging	p. 3
Observation of Aging	p. 17
Experimental Tests of the Evolutionary Theory of Aging	p. 39
Genetic Mechanisms for the Evolution of Aging	p. 62
Comparative Biology of Aging	p. 79
An Evolutionary Perspective on Organismal Theories of Aging	p. 99
An Evolutionary Perspective on Cellular and Molecular Theories of Aging	p. 126
The Future of Gerontology	p. 160
Bibliography	p. 187
Author Index	p. 211
Subject Index	p. 217
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