Top
| Contributors | |
| Preface to the Series | |
| Preface | |
| Why Experimental Headache Models? | p. 3 |
| Models in Early Drug Screening | p. 11 |
| Migraine: More Advanced Experimental Models for Drug Development | p. 19 |
| General Characteristics of Clinical Surrogates | p. 27 |
| Discussion Summary | p. 33 |
| Visceral Pain Mechanisms: Relevance to Migraine | p. 39 |
| Molecular Markers of Nociception | p. 49 |
| Drug Discovery in Migraine Circa 1995 | p. 63 |
| Studies of Cerebrovascular Pain Pathways of Relevance to Migraine | p. 75 |
| Studies on the Central and Peripheral Effects of a 5-HT[subscript 1D] Agonist and an NK[subscript 1] Antagonist on the Consequences of Trigeminal Activation in the Rat | p. 83 |
| Autoradiographic Mapping of [[superscript 3]H] Sumatriptan Binding in Cat Brain Stem and Spinal Cord | p. 89 |
| Anatomical Relationships Between the Circadian and Cerebrovascular Systems: Experimental Studies in Higher Primates and Relevance to Vascular Cephalalgia | p. 95 |
| Calcitonin Gene-Related Peptide, But Not Substance P, Mediates the Increased Meningeal Blood Flow Elicited by Electrical Stimulation of Rat Dura Mater Encephali | p. 101 |
| Noninvasive Detection of Hemoglobin Oxygenation Changes during Cortical Spreading Depression in the Rat Brain | p. 107 |
| Changes in Extracellular Glutamate Concentration Associated with Propagating Cortical Spreading Depression | p. 113 |
| Discussion Summary | p. 119 |
| Migraine: Relationship to Cloned Canine and Human 5-HT[subscript 1D] Receptors | p. 125 |
| Somatostatin and the Regulation of Pain | p. 135 |
| Human Cranial Arteries as an In Vitro Model of Migraine | p. 143 |
| CP-0578: A Compound with Antagonist Activity at Both Bradykinin BK[subscript 2] and Neurokinin NK[subscript 1] Receptors | p. 153 |
| VS-395: A Potent and Selective Agonist at 5-HT[subscript 1D] Receptors | p. 157 |
| Long-Acting 5-HT[subscript 1D] Receptor Agonist Effects of Dihydroergotamine: Studies Using a Model to Differentiate Slow Drug-Receptor Dissociation from Diffusion | p. 163 |
| Peripheral 5-Hydroxytryptaminergic Model in Headache Research | p. 169 |
| Sumatriptan and Platelet Aggregability: Indirect Evidence of 5-HT[subscript 1]-Like Receptors | p. 175 |
| Endothelin Receptors in Human Meningeal Artery | p. 179 |
| Discussion Summary | p. 183 |
| Cranial Arteriovenous Shunting: An In Vivo Animal Model for Migraine | p. 189 |
| Cortical Spreading Depression | p. 199 |
| Trigeminal Mechanisms of Vascular Head Pain | p. 207 |
| Perfusion of the Meninges of the Rat and Recording in the Brain Stem: An Electrophysiological Model for Headache? | p. 217 |
| Systemic and Pulmonary Vascular Effects of Sumatriptan in Anesthetized Rats | p. 223 |
| Systemic Nitroglycerin Induces Fos Immunoreactivity in Rat Brain: A Possible Model for Migraine? | p. 229 |
| Calcitonin Gene-Related Peptide: Hemodynamics and Carotid Blood Flow Distribution in the Anesthetized Pig | p. 235 |
| Changes in Spinal Cord and Cortical Evoked Responses to Dural Electrical Stimulation Following Trigeminal Ganglion Stimulation | p. 239 |
| Discussion Summary | p. 245 |
| Nitroglycerin-Induced Headache: An Experimental Human Headache Model | p. 251 |
| Experimental Headache Induced by Histamine, meta-Chlorphenylpiperazine, and Reserpine | p. 259 |
| Prostacyclin, Tyramine, and Red Wine | p. 267 |
| Exteroceptive Suppression of Temporalis Muscle Activity in a Laboratory Model Reflecting Effects of Sumatriptan during Migraine Interval and Migraine Attacks in Humans | p. 277 |
| Clinical and Intracerebral Hemodynamic Changes during L-Arginine Infusion in Migraine | p. 283 |
| Effects of Sumatriptan on Visually Evoked Event-Related Potentials | p. 289 |
| Discussion Summary | p. 293 |
| Experimental Models of Tension-Type Headache | p. 297 |
| Models in Cluster Headache | p. 303 |
| Short-Term Edema of the Masseter Muscle after Prolonged Isometric Contraction: A Precursor of Muscle Pain? | p. 313 |
| A New Methodology to Study Muscle Fatigue in Normal and Headache Patients | p. 319 |
| The Validation of Experimental Algesimetric Pain Models by Quasi-Experimental Clinical Headache | p. 325 |
| Effects of Peppermint and Eucalyptus Oil Preparations on Neurophysiological and Experimental Algesimetric Headache Parameters | p. 331 |
| Middle Cerebral Artery Blood Velocity Increases during Experimental Pressure Pain in the Head | p. 337 |
| Discussion Summary | p. 341 |
| Future Development of Drugs for Headache Disorders | p. 345 |
| Subject Index | p. 351 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
