Experimental Organic Chemistry A Miniscale and Microscale Approach (with CD-ROM)

by Unknown

• ISBN13: 9780030340635
• ISBN10: 0030340632
• Edition: 3rd
• Format: Hardcover
• Copyright: 2001-10-09
• Publisher: Brooks Cole

Summary

This proven and well-tested laboratory manual for organic chemistry students contains procedures for both miniscale (also known as small scale) and microscale users. This lab manual gives students all the necessary background to enter the laboratory with the knowledge to perform the experiments with confidence. For the microscale labs, experiments were chosen to provide tangible quantities of material, which can then be analyzed. Chapters 1-2 introduce students to the equipment, record keeping, and safety of the laboratory. Chapters 3-6, and 8 are designed to introduce students to laboratory techniques needed to perform all experiments. In Chapters 7 and 9 through 20, students are required to use the techniques to synthesize compounds and analyze their properties. In Chapter 21, students are introduced to multi-step syntheses of organic compounds, a practice well known in chemical industry. In Chapter 23, students are asked to solve structures of unknown compounds. The new chapter 24 introduces a meaningful experiment into the textbook that reflects the increasing emphasis on bioorganic chemistry in the sophomore-level organic lecture course. This experiment not only gives students the opportunity to accomplish a mechanistically interesting and synthetically important coupling of two a-amino acids to produce a dipeptide but also provides valuable experience regarding the role of protecting groups in effecting synthetic transformations with multiple functionalized molecules.

Table of Contents

1. Introduction, Record Keeping, and Laboratory Safety

2. Techniques and Apparatus

3. Solids: Recrystallization and Melting Points

4. Liquids

5. Extraction

6. Chromatography

7. Stereoisomers

8. Spectral Methods

9. Alkanes

10. Alkenes

11. Alkynes

12. Dienes: The Diels-Alder Reaction

13. Kinetic and Thermodynamic Control of a Reaction

14. Nucleophilic Aliphatic Substitution: Preparation for Alkyl Halides

15. Electrophilic Aromatic Substitution

16. Oxidation of Alcohols and Carbonyl Compounds

17. Reduction Reactions of Double Bonds: Alkenes, Carbonyl Compounds, and Imines

18. Reactions of Carbonyl Compounds

19. Organometallic Chemistry

20. Carboxylic Acids and Their Derivatives

21. Polymers

22. Carbohydrates

23. Identifying Organic Compounds

24. The Literature of Organic Chemistry