Leading academic and biomedical researchers comprehensively review the status of essential fatty acids (EFA) in nutrition, medicine, psychology, and pharmacology. Topics range from a discussion of EFA basic mechanisms to their effects on individual psychiatry and behavior, and include extensive coverage of pathology, DHA in CNS development, and phospholipid and fatty acid composition and metabolism. Comprehensive and forward-looking, Fatty Acids: Physiological and Behavioral Functions reviews and critically evaluates our current knowledge of EFA, setting the stage for oncoming wave of discovery about the biochemical and molecular functions of essential fatty acids, as well as their critical role in human physiology, immunology, and behavior.

Series Editor Page

v

Foreword

vii

Ralph Holman

Foreword

ix

William Lands

Preface

xvii

Contributors

xxiii

Part I Basic Mechanisms

Evolutionary Aspects of Diet: Essential Fatty Acids

3

(20)

Artemis P. Simopoulos

Modulation of Receptor Signaling by Phospholipid Acyl Chain Composition

23

(18)

Drake C. Mitchell

Burton J. Litman

Role of Docosahexaenoic Acid in Determining Membrane Structure and Function: Lessons Learned from Normal and Neoplastic Leukocytes

41

(22)

Laura J. Jenski

William Stillwell

Effects of Essential Fatty Acids on Voltage-Regulated Ionic Channels and Seizure Thresholds in Animals

63

(16)

Robert A. Voskuyl

Martin Vreugdenhil

Role of Dietary Fats and Exercise in Immune Functions and Aging

79

(20)

Jaya T. Venkatraman

David Pendergast

Part II Phospholipid and Fatty Acid Composition and Metabolism

On the Relative Efficacy of α-Linolenic Acid and Preformed Docosahexaenoic Acid as Substrates for Tissue Docosahexanoate During Perinatal Devlopment

99

(16)

Meng-Chuan Huang

J. Thomas Brenna

Recent Advances in the Supply of Docosahexaenoic Acid to the Nervous System

115

(10)

Robert J. Pawlosky

Norman Salem Jr.

Quantifying and Imaging Brain Phospholipid Metabolism In Vivo Using Radiolabeled Long Chain Fatty Acids

125

(20)

Stanley I. Rapoport

Carbon Recycling: An Important Pathway in α-Linolenate Metabolism in Fetuses and Neonates

145

(14)

Stephen C. Cunnane

Part III DHA and CNS Development

Impact of Dietary Essential Fatty Acids on Neuronal Structure and Function

159

(18)

M. Thomas Clandinin

R.A.R. Bowen

Miyoung Suh

Dietary N-3 Fatty Acid Deficiency and its Reversibility: Effects upon Brain Phospholipids and the Turnover of Docosahexaenoic Acid in the Brain and Blood

177

(16)

William E. Connor

Gregory J. Anderson

Don S. Lin

The Role of Omega-3 Polyunsaturated Fatty Acids in Retinal Function

193

(26)

Algis J. Vingrys

James A. Armitage

Harrison S. Weisinger

B.V. Bui

Andrew J. Sinclair

Richard S. Weisinger

Brightness-Discrimination Learning Behavior and Retinal Function Affected by Long-Term α-Linolenic Acid Deficiency in Rat

219

(20)

Harumi Okuyama

Yoichi Fujii

Atsushi Ikemoto

Part IV Pathology

Disturbances of Essential Fatty Acid Metabolism in Neural Complications of Diabetes

239

(18)

Joseph Eichberg

Cristinel Miinea

Docosahexaenoic Acid Therapy for Disorders of Peroxisome Biogenesis

257

(16)

Hugo W. Moser

Gerald V. Raymond

Effects of Fatty Acids and Ketones on Neuronal Excitability: Implications for Epilepsy and its Treatment

273

(18)

Carl E. Stafstrom

Fatty Acid Ethyl Esters: Toxic Nonoxidative Metabolites of Ethanol

291

(20)

Zbigniew M. Szczepiorkowski

Michael Laposata

Part V Psychiatry and Behavior

Omega-3 Fatty Acids and Psychiatric Disorders: Current Status of the Field

311

(20)

Joseph R. Hibbeln

Norman Salem Jr.

Disorders of Phospholipid Metabolism in Schizophrenia, Affective Disorders, and Neurodegenerative Disorders

331

(14)

David F. Horrobin

Eicosapentaenoic Acid: A Potential New Treatment for Schizophrenia?

345

(12)

Malcolm Peet

Shaun Ryles

The Importance of DHA in Optimal Cognitive Function in Rodents

357

(20)

Claus C. Becker

David J. Kyle

The Role of Omega-3 Polyunsaturated Fatty Acids in Body Fluid and Energy Homeostasis

377

(26)

Richard S. Weisinger

James A. Armitage

Peta Burns

Andrew J. Sinclair

Algis J. Vingrys

Harrison S. Weisinger

PUFA: Mediators for the Nervous, Endocrine, and Immune Systems

403

(18)

Shlomo Yehuda

Sharon Rabinovitz

David I. Mostofsky

Glossary

421

(4)

Index

425

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