Flavonoid Pharmacokinetics Methods of Analysis, Preclinical and Clinical Pharmacokinetics, Safety, and Toxicology

by Davies, Neal M.; Yá; ñ; ez, Jaime A.; Roufogalis, Basil

• ISBN13: 9780470578711
• ISBN10: 0470578718
• Edition: 1st
• Format: Hardcover
• Copyright: 2012-12-03
• Publisher: Wiley

Summary

Highlighting the extremely important preclinical aspects of flavonoids, including pharmacokinetics and analysis in biological samples, Flavonoid Pharmacokinetics covers the methods of analysis and pharmacokinetics (preclinical and clinical) of flavonoids to help readers comprehend pharmacokinetic terminology, understand the large number of compounds that encompass the flavonoid family, appreciate the multiple analytical methods available, and assess preclinical and clinical pharmacokinetics of flavonoids and similar chemical-derived compounds. The book uses applicable examples in different preclinical species and humans to strengthen pharmacokinetic concepts and to demonstrate how they apply on the preclinical and clinical drug development process.

Author Biography

Neal M. Davies, PhD. is Dean of Professor in the Faculty of Pharmacy at the University of Manitoba. He has also held faculty positions at the University of Sydney and Washington State University. Dr. Davies’s research focuses on pharmaceutics and the pharmacokinetics and pharmacodynamics of natural products. He is a graduate of the University of Alberta.

Jaime A. Yáñez, PhD. is Senior Study Director in Drug Metabolism and Pharmacokinetics at Alcon Research, Ltd., a Novartis Company. Previously, he worked at Schering-Plough Research Institute and Merck Research Laboratories. He also serves as Adjunct Faculty and Research Consultant at Universities and research organizations in Peru, Mexico, Spain and the United States. Dr. Yáñez’s expertise spans preclinical and clinical pharmacokinetics, pharmacodynamics, pharmaceutics, and predictive computer modeling and simulation, all with an emphasis on natural products.

Table of Contents

Preface

Contributors

1 Polyphenols and Flavonoids: An Overview

2 Analysis of Flavonoids through Chromatography

3 Chiral Methods of Flavonoid Analysis

4 Pre-Clinical Pharmacokinetics of Flavonoids

5 Clinical Pharmacokinetics of Flavonoids

6 Toxicology and Safety of Flavonoids

7 Flavonoids and Drug Interactions

Index