Fluorinated Heterocyclic Compounds Synthesis, Chemistry, and Applications

by Petrov, Viacheslav A.

• ISBN13: 9780470452110
• ISBN10: 0470452110
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-09-28
• Publisher: Wiley

Summary

Fluorinated compounds have distinctive desirable properties suitable for use in pharmaceuticals and agrichemicals, especially their ability to penetrate the cell membrane barrier for drug absorption. This essential reference provides the latest state-of-the-art information on key application areas within fluorine chemistry. With contributions from experts from both industry and academia, the book covers the chemistry, synthesis and applications of fluorinated heterocycles with chapters on three-, four-, five-, six- and seven-membered fluorine-containing heterocycles, fluorinated nucleosides, and fluorointermediates and fluoropolymers.

Author Biography

Viacheslav A. Petrov is a Research Fellow with DuPont Central Research and Development in Wilmington, Delaware.

Table of Contents

Preface	p. vii
Contributors	p. xi
Introduction: Nomenclature of Polyfluorinated Heterocycles	p. xiii
Synthesis and Chemistry of Fluorinated Heterocycles	p. 1
Fluorinated Three-Membered Ring Heterocycles	p. 3
Fluorinated Four-Membered Heterocycles	p. 65
Fluorinated Five-Membered Nitrogen-Containing Heterocycles	p. 91
Fluorinated Five-Membered Heterocycles Containing Oxygen, Sulfur, Selenium, and Phosphorus	p. 159
Synthesis of Fluorinated Sugars from Fluorine-Containing Synthons	p. 227
Synthesis of Ring-Fluorinated Pyridines	p. 243
Synthesis and Chemical Transformation of Six-Membered Aromatic Heterocycles Containing Perfluoroalkyl Groups	p. 273
Perfluorinated Six-Membered Aromatic Heterocycles Containing One or More Heteroatom	p. 303
Perfluorinated Nonaromatic Heterocycles	p. 325
Seven-Membered and Larger Ring-Fluorinated Heterocycles	p. 361
Application of Fluorinated Heterocyclic Materials	p. 397
Agricultural Products Based on Fluorinated Heterocyclic Compounds	p. 399
Pharmaceuticals Containing Fluorinated Heterocyclic Compounds	p. 419
Practical Uses of Fluorinated Heterocycles	p. 493
Index	p. 507
Table of Contents provided by Ingram. All Rights Reserved.