Folate and Human Development

by Massaro, Edward J.; Rogers, John M.

• ISBN13: 9780896039360
• ISBN10: 0896039366
• Format: Hardcover
• Copyright: 2002-03-01
• Publisher: Humana Pr Inc

Summary

An authoritative panel of basic and clinical researchers critically reviews the latest findings on the role of folate in human development, health, and disease. Specific areas addressed include folate metabolism in zinc or copper deficiencies, choline and folate in development, animal models of folate-related birth defects, developmental toxicants potentially acting via folate perturbation, and folate's role in vascular disease in women. There are also cutting-edge discussions of genes and neural tube development, folate receptor polymorphism and the risk for neural defects, abnormal DNA synthesis and methylation with folate/methyl insufficiency, and folic acid and homocysteine as risk factors for neural tube defects.

Table of Contents

Preface	v
Contributors	xi
Animal Models of Folate-Related Neural Tube Defects	1	(26)
Nicholas D. E. Greene
Andrew J. Copp
Genetic Variation in Folate Metabolism: Impact on Development	27	(16)
Rima Rozen
Folate Deficiency and the Molecular Determinants of Chromosome Instability: Possible Link to Meiotic Nondisjunction and Down Syndrome	43	(28)
S. Jill James
Charlotte A. Hobbs
Folic Acid, Vitamin B12, and Genomic Stability of Human Cells	71	(20)
Michael Fenech
Molecular Genetics of Folate Metabolism	91	(26)
Manuela Fodinger
Sonja Skoupy
Gere Sunder-Plassmann
Folate Receptor-α: An Update	117	(20)
Barton A. Kamen
Folate, Homocysteine, and Neural Tube Defects	137	(28)
Tom K. A. B. Eskes
Folic Acid and Homocysteine as Risk Factors for Neural Tube Defects	165	(18)
Robert C. Barber
Janee van Waes
Edward J. Lammer
Gary M. Shaw
Thomas H. Rosenquist
Richard H. Finnell
Developmental Toxicants Potentially Acting via Folate Perturbation	183	(22)
Deborah K. Hansen
Brain Development and Choline, the Other Methyl Donor	205	(14)
Steven H. Zeiset
Nutrient Interactions Between Folate and Zinc or Copper: Their Possible Implications to Pregnancy Outcome	219	(22)
Tsunenobu Tamura
Regulation of Folate Metabolism by Iron	241	(22)
A. Katherine Herbig
Patrick J. Stover
A Differential Role for Folate in Developmental Disorders, Vascular Disease, and Other Clinical Conditions: The Importance of Folate Status and Genotype	263	(36)
Mark Lucock
Zoe Yates
Vascular Disease in Women: Folate and Homocysteine	299	(30)
Tom K. A. B. Eskes
Folate, Homocysteine, and Cardiovascular Disease	329	(16)
Jayne V. Woodside
Ian S. Young
Index	345