Foye's Principles of Medicinal Chemistry

by Williams, David A.; Foye, William O.; Lemke, Thomas L.

• ISBN13: 9780683307375
• ISBN10: 0683307371
• Edition: 5th
• Format: Hardcover
• Copyright: 2002-02-15
• Publisher: LWW

Summary

This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist a therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.

Table of Contents

Introduction Origins of Medicinal Chemistry	1	(10)
William O. Foye
Part I Principles of Drug Discovery	11	(234)
Overview Drug Design and Development: A Perspective	12	(12)
Michael Williams
Natural Products	24	(13)
Alice M. Clark
Drug Design and Relationship of Functional Groups to Pharmacologic Activity	37	(31)
James J. Knittel
Robin M. Zavod
Molecular Modeling and Drug Design	68	(18)
Eric Billings
Receptors and Drug Action	86	(14)
Timothy J. Maher
David A. Johnson
Drug Design Through Enzyme Inhibition	100	(14)
Stephen G. Kerr
Peptide and Protein Drugs	114	(29)
Michael Mokotoff
Physicochemical and Biopharmaceutical Properties of Drug Substances and Pharmacokinetics	143	(31)
Sunil Jambhekar
Drug Metabolism	174	(60)
David A. Williams
U.S. Drug Regulation: An Overview	234	(11)
Douglas J. Pisano
Part II Pharmacodynamic Agents	245	(19)
Overview Drug Receptors: A Perspective	246	(18)
David J. Triggle
Section 1 Drugs Affecting Neurotransmission	264	(93)
Drugs Affecting Cholinergic Neurotransmission	264	(28)
Danny L. Lattin
E. Kim Fifer
Drugs Affecting Adrenergic Neurotransmission	292	(23)
Robert Griffith
Serotonin Receptors and Drugs Affecting Serotonergic Neurotransmission	315	(23)
Richard A. Glennon
Malgorzata Dukat
Local Anesthetics	338	(19)
Matthias C. Lu
Section 2 Drugs Affecting Central Nervous System	357	(140)
Volatile Anesthetics	357	(13)
Timothy J. Maher
Hypnotics	370	(14)
William Soine
Antiseizure Drugs	384	(24)
Barbara W. Leduc
Psychotherapeutic Drugs: Antipsychotic and Anxiolytic Agents	408	(26)
Raymond G. Booth
John L. Neumeyer
Hallucinogens, Stimulants, and Related Drugs of Abuse	434	(19)
Richard A. Glennon
Opioid Analgesics	453	(27)
David S. Fries
Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonian and Spasmolytic Agents	480	(17)
Raymond G. Booth
John L. Neumeyer
Section 3 Drugs Affecting the Cardiovascular System	497	(132)
Cardiac Agents: Cardiac Glycosides, Antianginal, and Antiarrhythmic Drugs	497	(21)
Ahmed S. Mehanna
Diuretics	518	(15)
Gary O. Rankin
Angiotensin Converting Enzyme Inhibitors, Antagonists and Calcium Blockers	533	(29)
Marc W. Harrold
Central and Peripheral Sympatholytics and Vasodilators	562	(18)
David A. Williams
Antihyperlipoproteinemics and Inhibitors of Cholesterol Biosynthesis	580	(24)
Marc W. Harrold
Antithrombotics, Thrombolytics, Coagulants and Plasma Extenders	604	(25)
Robert B. Palmer
Section 4 Drugs Affecting the Hormonal Systems	629	(122)
Insulin and Oral Hypoglycemic Drugs	629	(24)
Robert A. Wiley
Adrenocorticoids	653	(32)
Duane D. Miller
Robert W. Brueggemeier
James T. Dalton
Estrogen, Progestins and Androgens	685	(33)
Robert W. Brueggemeier
Duane D. Miller
James T. Dalton
Thyroid Function and Thyroid Drugs	718	(21)
Ali R. Banijamali
Calcium Homeostasis	739	(12)
Robin M. Zavod
Section 5 Drugs Affecting the Immune Systems	751	(68)
Nonsteroidal Anti-Inflammatory Agents	751	(43)
Ronald F. Borne
Antihistamines and Related Antiallergic and Antiulcer Agents	794	(25)
Wendel L. Nelson
Section 6 Chemotherapeutic Agents	819	(162)
Antibiotics and Antimicrobial Agents	819	(48)
Lester A. Mitscher
Antiparasitic Agents	867	(24)
Thomas L. Lemke
Antifungal Drugs	891	(13)
Robert Griffith
Timothy Tracy
Antimycobacterial Agents	904	(20)
Thomas L. Lemke
Cancer and Cancer Chemotherapy	924	(28)
Patrick S. Callery
Peter M. Gannett
Antiviral Agents and Protease Inhibitors	952	(29)
Manohar L. Sethi
Part III Recent Advances in Drug Discovery	981	(89)
Pharmaceutical Biotechnology	982	(34)
Robert D. Sindelar
Gene Therapy	1016	(36)
Ronald E. Reid
Antisense Therapeutic Agents	1052	(7)
Marilyn K. Speedie
Selective Estrogen Receptor Modulators	1059	(11)
V. Craig Jordan
Appendices pKa Values for Some Drugs and Miscellaneous Organic Acids and Bases pH Values for Tissue Fluids	1070
David A. Williams