Free Radicals in Biology and Medicine

by Halliwell, Barry; Gutteridge, John M. C.

• ISBN13: 9780198552949
• ISBN10: 0198552947
• Edition: 2nd
• Format: Hardcover
• Copyright: 1990-03-01
• Publisher: Oxford University Press

Summary

"This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), whilst maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of ageing and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet." "This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and medical sciences."--BOOK JACKET.

Author Biography

John Gutteridge is Director of the Oxygen Chemistry Laboratory, Royal Brompton and Harefield NHS Trust, London. Barry Halliwell is Deputy President in charge of all Research and Technology at the National University of Singapore.

Table of Contents

Oxygen is a toxic gas - an introduction to oxygen toxicity and reactiveoxygen species

The Chemistry of Free radicals and Related "Reactive Species"

Antioxidant Defences

Oxidative Stress: Adaptation, Damage, Repair and Death

Detection of Free Radicals and Other Reactive Species

Trapping andFingerprinting

Reactive Species as Useful Biomolecules

Oxidative Stress and Antioxidant Protection: Some Special Cases

Free Radicals, "Reactive Species" and Toxicology

Free Radicals, Other Reactive Species and Disease

Ageing, Nutrition, Disease and Therapy

A Role for Antioxidants?

Some Basic Chemistry for the Life Scientist

Some Basic Molecular Biology for the Chemist

Table of Contents provided by Publisher. All Rights Reserved.