Free Radicals and Inflammation

by Winyard, Paul G.

• ISBN13: 9783764358518
• ISBN10: 3764358513
• Format: Hardcover
• Copyright: 2000-02-01
• Publisher: Springer Verlag

Summary

The book deals with the role of both oxygen- and nitrogen-centred free radicals in inflammatory diseases such as rheumatoid arthritis. The well-known involvement of the superoxide anion radical in the bactericidal action of inflammatory cells suggests that radicals and the inflammatory response are inextricably linked. The widespread involvement of radicals in human disease seems inevitable, because inflammation is such a conspicuous component of human disease. For the first time, the present text integrates contributions from leading research groups who have been investigating the role of radicals within the context of all stages of inflammtion, such as the recruitment of inflammatory cells, their bactericidal action, inflammatory tissue destruction and inflammatory cell death by apoptosis. The chapters are broadly organised so that they trace the clinical course of the acute and chronic inflammtory response, emphasising the therapeutic implications of recent data on the contribution of nitric oxide and related nitrogen-centred species. The book will be of interest to academic and industrial researchers and clinicians with interests in the fields of inflammation or free radical biology.

Table of Contents

List of contributors	vii
Preface	xi
David R. Blake
Paul G. Winyard
Chris H. Evans
Introduction	1	(10)
David R. Blake
Tulin Bodamyali
Cliff R. Stevens
Paul G. Winyard
Reactive oxygen/nitrogen species and acute inflammation: A physiological process	11	(6)
Tulin Bodamyali
Cliff R. Stevens
David R. Blake
Paul G. Winyard
Free radicals and pathology: current concepts	17	(4)
David R. Blake
Tulin Bodamyali
Cliff R. Stevens
Paul G. Winyard
The NADPH oxidase of neutrophils and other cells	21	(26)
Owen T.G. Jones
John T. Hancock
Nitric Oxide --- a novel antimicrobial agent	47	(18)
Nigel Benjamin
Xanthine oxidoreductase	65	(18)
Roger Harrison
Inflammatory mediators, free radicals and gene transcription	83	(16)
Vanessa Gilston
David R. Blake
Paul G. Winyard
Reactive metabolites of oxygen and nitrogen, adhesion molecule expression and chronic joint inflammation	99	(20)
Matthew B. Grisham
Robert E. Wolf
Role of thioredoxin in the redox regulation of gene expression in inflammatory diseases	119	(14)
Takashi Okamoto
Toshifumi Tetsuka
Reactive oxygen species and the regulation of metalloproteinase expression	133	(22)
Yvonne Y.C. Lo
Johnson M.S. Wong
Wing-Fai Cheung
Tony F. Cruz
Nitric Oxide and inflammatory joint diseases	155	(14)
Chris H. Evans
Maja Stefanovic-Racic
Nitric oxide and bone destruction	169	(14)
Heather MacPherson
Stuart H. Ralston
Why does chronic inflammation persist? A radical autoimmune perspective	183	(12)
Joseph Lunec
Helen R. Griffiths
Radicals, granuloma formation and fibrosis	195	(12)
George A.C. Murrell
Reactive oxygen species, nitric oxide and apoptosis	207	(14)
Christopher A. Bombeck
Jianrong Li
Timothy R. Billiar
Evolving measurements of radical products --- how much do they tell us about inflammation?	221	(20)
Harparkash Kaur
Barry Halliwell
Do antioxidants have a role in the therapy of human inflammatory diseases?	241	(12)
Sally Edmonds
Index	253