From Molecular to Modular Tumor Therapy

by Reichle, Albrecht

• ISBN13: 9789048195305
• ISBN10: 9048195306
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-10-01
• Publisher: Springer Nature

Summary

The traditional problem of the poor presentability as well as diagnostic and therapeutic practicability of individual patient care is still unresolved. The present book aims at leading the reader (cancer researchers, pharmacologists, biologists) away'•in a scientifically accessible manner'•from the daily conflicts between theory and practice and between the generalized and individual tumor patient, so that more personalized diagnostic and therapeutic strategies can be developed for controlling metastatic tumor disease:'¢ First, recording the systems concept of tumor biology based on rather different sciences (biochemistry, cell biology, and medical oncology) including their potential contribution to communication, '¢ then, giving reductionistically derived systems features an internal communicative context (formal-pragmatic communication theory), and '¢ finally, binding the systems features to (tumor-immanent) evolutionary processes (modularity of biochemical and cellular processes,rat.

Table of Contents

Therapy-Derived Systems Biology: A Pragmatic Communication Theory
Bridging Theory and Therapeutic Practice: From Generalized Disease Models to Particular Patients	p. 3
Tumor Systems Need to be Rendered Usable for a New Action-Theoretical Abstraction: The Starting Point for Novel Therapeutic Options	p. 9
Principles of Modular Tumor Therapy	p. 29
Tumors Share Common Processes During Tumor Evolution: Communicative Aspects of a Situation's Interpretation for Creating Systems-Directed Therapies
Cancer and Coagulation; Focusing on Tissue Factor and Heparanase	p. 51
The Role of Mesenchymal Cells in Cancer: Contribution to Tumor Stroma and Tumorigenic Capacity	p. 75
Shaping Tumor Associated Macrophages: The Role of NF-kB	p. 97
The Metabolic Achilles Heel: Tumor Cell Metabolism as Therapeutic Target	p. 111
Could Be Systems-Directed Therapy Approaches Promising in Glioblastoma Patients?	p. 133
Systems-Relevant Molecular and Cellular Targets: Implementation of Modular 'Knowledge'
Functional Impacts of Signal Integration: Regulation of Inflammation-Related Transcription Factors by Heterotrimeric G Proteins	p. 161
Molecular Cross-Talk Between Nuclear Receptors and Nuclear Factor-kB	p. 191
The Biomodulatory Capacities of Low-Dose Metronomic Chemotherapy: Complex Modulation of the Tumor Microenvironment	p. 243
Tumors are Evolvable Modular and Rationalized Systems: From Molecular to Modular Tumor Therapy
Systems Biology: A Therapeutic Target for Tumor Therapy	p. 265
The Comparative Uncovering of Tumor Systems Biology by Modularly Targeting Tumor-Associated Inflammation	p. 287
Searching for the 'Metabolism' of Evolution	p. 305
Biomodulatory Therapy Approaches in Metastatic Cancer
The Impact of Inflammation Control and Active Cancer Palliation on Metabolic Pathways Determining Tumor Progression and Patient Survival	p. 313
Pioglitazone and Rofecoxib Combined with Angiostatically Scheduled Capecitabine in Far-Advanced Hepatobiliary Carcinoma	p. 341
C-Reactive Protein As a Secretome-Derived Biomarker for Predicting Response to Biomodulatory Therapy in Metastatic Renal Clear Cell Carcinoma	p. 353
Modular Therapy Approach in Metastatic Castration-Resistent Prostate Cancer	p. 367
Systems-Directed Therapy in Metastatic Castration-Resistent Prostate Cancer (CRCP)	p. 379
Criteria for Checking Systems Behavior and Creating Predictions: Systems-Associated Biomarkers and Molecular Imaging
Early Detection of Systems Response: Molecular and Functional Imaging of Angiogenesis	p. 385
Secretome Proteomics, a Novel Tool for Biomarkers Discovery and for Guiding Biomodulatory Therapy Approaches	p. 405
Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma	p. 433
Pharmacological Considerations on Systems Biological Therapy Approaches
Uncovering Tumor Systems Biology by Biomodulatory Therapy Strategies	p. 469
Breathing New Life into Old Drugs: Indication Discovery by Systems Directed Therapy	p. 483
Tumors' Systems Biology: Implications for Personalized Therapy
A Methodological Approach to Personalized Therapies in Metastatic Cancer	p. 507
Summary
To Be an Object in a Biological System: The Necessity of a Formal-Pragmatic Communication Theory	p. 537
From Molecular to Modular, from Theme-Dependent to Evolution-Adjusted Tumor Therapy	p. 545
Index	p. 557
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