From Molecules to Networks

by Byrne; Heidelberger; Waxham; Roberts

• ISBN13: 9780123741325
• ISBN10: 0123741327
• Edition: 2nd
• Format: Hardcover
• Copyright: 2009-01-23
• Publisher: Elsevier Science

Summary

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease. KEY FEATURES: . Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook. The second edition now includes an introduction to mathematical modeling and simulation approaches as the first textbook of molecular and cellular neuroscience . Now includes a chapter on the Neurobiology of Disease . Discusses emerging new understanding of non-classical molecules that affect neuronal signaling . Full colour, professional graphics throughout . Includes two new chapters: * Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. * Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer's disease. . Two expansive, frequently updated support websites: one for students, with additional study materials, updated further reading references, and quizzes; and one for instructors, providing all figures, solutions to quizzes and further materials, PowerPoint lecture slides, and more.

Table of Contents

Cellular Components of Nervous Tissue

Subcellular Organization of the Nervous System: Organelles and Their Functions

Energy Metabolism in the Brain

Electronic Properties of Axons and Dendrites

Membrane Potential and Action Potential

Molecular Properties of Ion Channels

Dynamical Properties of Excitable Membranes

Release of Neurotransmitters

Pharmacology and Biochemistry of Synaptic Transmission: Classic Transmitters

Peptides, Growth Factors, Gasses and Other Neurotransmitters

Neurotransmitter Receptors

Intracellular Signalling

Regulation of Neuronal Gene Expression and Protein Synthesis

Mathematical Modeling and Analysis of Intracellular Signaling Pathways

Connexin- and Pannexin-Based Channels in the Nervous System: Gap Junctions and More

Postsynaptic Potentials and Synaptic Integration

Complex Information Processing in Dendrites

Information Processing in Neural Networks

Learning and Memory: Basic Mechanisms

Molecular and Cellular Mechanisms of Neurodegenerative Disease

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