Frontiers in Biochip Technology

by Xing, Wan-Li; Cheng, Jing

• ISBN13: 9780387255682
• ISBN10: 0387255680
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-02-28
• Publisher: Springer Verlag

Summary

Frontiers in Biochip Technology Dr. Wan-Li Xing and Dr. Jing Cheng Frontiers in Biochip Technology serves as an essential collection of new research in the field of biochip technology. This comprehensive collection covers emerging technologies and cutting a??edge research in the field of biochip technology, with all chapters written by the international stars of this evolving field. Key topics and current trends in biochip technology covered include: -microarray technology and its applications - microfluidics - drug discovery - detection technology - lab-on-chip technology and bioinformatics. Frontiers in Biochip Technology is an important volume for all biotechnologists, bioengineers, genetic engineers, pharmacological researchers, and general bench researchers who want to be up-to-date on the latest advances in the rapidly growing field of biochip technology. The Editors: Dr. Wan-Li Xing , Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China Dr. Xing is a Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, and also serves as the Executive Deputy Director at NERCBBT, CapitalBio Corporation, a world-leader in biochip research. Dr. Xing has published widely and obtained many patents and applications. Dr. Jing Cheng , Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China Dr. Jing Cheng is the Cheung Kong Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, the Director of NERCBBT and CEO & CTO of CapitalBio. Dr. Cheng developed the worlda??s first system of laboratory-on-a-chip in 1998; this work was featured in the front-cover story of the June 1998 issue of Nature Biotechnology and cited as the breakthrough of the year by Science in the same year. He has been awarded Nanogena??s most prestigious award Nano Grant, Distinguished Achievement Award for Overseas Chinese Scholars Returned, Chinaa??s Science & Technology Award for Outstanding Youth, and Qiushi Technology Transfer Award for Outstanding Youth. Dr. Cheng has published over 90 peer-reviewed papers. In addition, he has obtained over 60 European and U.S. patents and applications.

Table of Contents

A Homogenous Microarray for Enzymatic Functional Assays: Chemical Compound Microarray

Improvement of Microarray Technologies for Detecting Single Nucleotide Mismatch

Miniaturised Multiplexed Protein Binding Assays

MEA-Based Spike Recording in Cultured Neuronal Networks

Cell-Transistor Hybrid Systems: Electrogenic Cells as Signal Transducing Elements Coupled to Microeletronic Devises

Microfabricated Chip Electrophoresis Technology for DNA Analysis

Microfabrication and Application of Recessed Gold Electrode in Microchip Electrophoresis System

Fast Screening of Single-Nucleotide Polymorphisms Using Chip-Based Temperature Gradient Capillary Electrophoresis

Electro-Osmotic Flow Micro Pumps for Cell Positioning in Biochips

The Application of Novel Multi-Functional Microarray Slides for Immobilization Biomolecules

Novel Surface Technologies for Genomics, Proteomics, and Drug Discovery

Photoactivatable Silanes: Synthesis and Uses in Biopolymer Array Fabrication on Glass Substrates

An Integrated Biochemoinformatics System for Drug Discovery: Managing and Mining Chemical Structure Information, Biological Activity Fingerprints, and Gene Expression Profiling Patterns

Development of the MGX 4D Array System Utilizing Flow-Thru Chip Technology: Performance Evaluation of the MGK 4D Array System for Gene Expression Analysis

Sequencing by Aligning Mutated DNA Fragments: A New Approach to Conventional Sequencing and SBH Sequencing

Fabrication of Double-Stranded DNA Microarray on Solid Surface for Studying DNA-Protein Interactions: A High-Throughout Platform for Profiling Bimolecular Interaction

Electronic Biosensors Based on DNA Self-Assembled Monolayer on Gold Electrodes

Multi-Parameter Read-Out in Miniaturized Format: Case Studies in Assay Development and High Throughput Screening

High Throughput Tissue in Microarray Technology for the Rapid Clinical Translation of Genomic Discoveries

Index

Table of Contents provided by Publisher. All Rights Reserved.