9780127877662

Functional Microbial Genomic: Methods in Microbiology

by
  • ISBN13:

    9780127877662

  • ISBN10:

    0127877665

  • Format: Paperback
  • Copyright: 2003-01-01
  • Publisher: Academic Pr
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Summary

Functional Microbial Genomics, edited by two leading experts in the field, provides the researcher with an up-to-date collection of articles on post-genome technologies central to studying the function of microorganisms.

Since the release of the first complete genome sequence of a free-living organism in 1995, over 100 microbial genomes have been completely sequenced. The advent of new technologies for post-genomic analyses has allowed the rapid exploitation of this genome sequence information, heralding a golden era in microbial research. Functional Microbial Genomics provides in-depth accounts from scientists working with these new technologies explaining both the techniques and the ways in which they have been applied to the study of gene function in different microbial species.

Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting edge protocols to directly benefit your research.

* Bioinformatic approaches to genome sequence analysis
* Details the design, construction and applications of DNA microarrays
* Covers advances in bacterial proteome and metagenome analysis
* Describes functional genomic approaches for novel antibiotic target and vaccine candidate discovery
* Presents case studies where functional genomic analyses have revolutionized our understanding of model species

Table of Contents

Contributors viii
Preface to the First Edition xiii
I Genome Sequence Analysis
Annotation of Microbial Genomes
3(24)
J Parkhill
From Sequence to Consequence: In Silico Hypothesis Generation and Testing
27(22)
M Pallen
The Atlas Visualization of Genomewide Information
49(18)
M Skovgaard
LJ Jensen
C Friis
HH Staerfeldt
P Worning
S Brunak
D Ussery
II Construction of DNA Microarrays
Microarray Design for Bacterial Genomes
67(16)
J Hinds
AA Witney
JK Vass
Glass Slide Microarrays for Bacterial Genomes
83(20)
J Hinds
KG Laing
JA Mangan
PD Butcher
III Comparative Nucleic Acid Analysis
Representational Difference Analysis of cDNA and Genome Comparisons
103(18)
DL Taylor
A Bart
LD Bowler
Application of DNA Microarrays for Comparative and Evolutionary Genomics
121(16)
N Dorrell
OL Champion
BW Wren
Gene Expression during Host-Pathogen Interactions: Approaches to Bacterial mRNA Extraction and Labelling for Microarray Analysis
137(16)
JA Mangan
IM Monahan
PD Butcher
High Throughput In Vivo Screens: Signature-tagged Mutagenesis
153(14)
N West
P Sansonetti
CM Tang
Further Strategies for Signature-tagged Mutagenesis and the Application of Oligonucleotide Microarrays for the Quantification of DNA-tagged Strains
167(20)
AV Karlyshev
N Dorrell
E Winzeler
BW Wren
IV Proteome Analysis
Advances in Bacterial Proteome Analysis
187(22)
SJ Cordwell
Discovery of Protein-Protein Interaction Using Two-hybrid Systems
209(32)
A Patel
KH Mellits
IF Connerton
V Applications of Microbial Genomics
Cloning the Metagenome: Culture-independent Access to the Diversity and Functions of the Uncultivated Microbial World
241(16)
J Handelsman
M Liles
D Mann
C Riesenfeld
RM Goodman
Reverse Vaccinology: from Genome to Vaccine
257(14)
JL Telford
M Pizza
G Grandi
R Rappuoli
Microbial Genomics for Antibiotic Target Discovery
271(20)
F Fan
D McDevitt
VI Case Studies -- Bacteria
Helicobacter pylori Functional Genomics
291(30)
KJ Guillemin
NR Salama
Streptomyces coelicolor A3(2): from Genome Sequence to Function
321(16)
KF Chater
G Bucca
P Dyson
K Fowler
B Gust
P Herron
A Hesketh
G Hotchkiss
T Kieser
V Mersinias
CP Smith
Functional Analysis of the Bacillus subtilis Genome
337(34)
CR Harwood
A Wipat
Z Pragai
VII Case Studies -- Parasites
Plasmodium falciparum DNA Microarrays and Interpretation of Data
371(12)
AA Witney
RM Anthony
TR Jones
DJ Carucci
Functional Analysis of the Plasmodium falciparum Genome Using Transfection
383(14)
AF Cowman
M Duraisingh
RA O'Donnell
T Triglia
BS Crabb
Chromosome Fragmentation as an Approach to Whole-genome Analysis in Trypanosomes
397(10)
JM Kelly
S Obado
Index 407

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