Functional Microbial Genomic: Methods in Microbiology

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  • Format: Paperback
  • Copyright: 2003-01-01
  • Publisher: Academic Pr
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Functional Microbial Genomics, edited by two leading experts in the field, provides the researcher with an up-to-date collection of articles on post-genome technologies central to studying the function of microorganisms.

Since the release of the first complete genome sequence of a free-living organism in 1995, over 100 microbial genomes have been completely sequenced. The advent of new technologies for post-genomic analyses has allowed the rapid exploitation of this genome sequence information, heralding a golden era in microbial research. Functional Microbial Genomics provides in-depth accounts from scientists working with these new technologies explaining both the techniques and the ways in which they have been applied to the study of gene function in different microbial species.

Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting edge protocols to directly benefit your research.

* Bioinformatic approaches to genome sequence analysis
* Details the design, construction and applications of DNA microarrays
* Covers advances in bacterial proteome and metagenome analysis
* Describes functional genomic approaches for novel antibiotic target and vaccine candidate discovery
* Presents case studies where functional genomic analyses have revolutionized our understanding of model species

Table of Contents

Contributors viii
Preface to the First Edition xiii
I Genome Sequence Analysis
Annotation of Microbial Genomes
J Parkhill
From Sequence to Consequence: In Silico Hypothesis Generation and Testing
M Pallen
The Atlas Visualization of Genomewide Information
M Skovgaard
LJ Jensen
C Friis
HH Staerfeldt
P Worning
S Brunak
D Ussery
II Construction of DNA Microarrays
Microarray Design for Bacterial Genomes
J Hinds
AA Witney
JK Vass
Glass Slide Microarrays for Bacterial Genomes
J Hinds
KG Laing
JA Mangan
PD Butcher
III Comparative Nucleic Acid Analysis
Representational Difference Analysis of cDNA and Genome Comparisons
DL Taylor
A Bart
LD Bowler
Application of DNA Microarrays for Comparative and Evolutionary Genomics
N Dorrell
OL Champion
BW Wren
Gene Expression during Host-Pathogen Interactions: Approaches to Bacterial mRNA Extraction and Labelling for Microarray Analysis
JA Mangan
IM Monahan
PD Butcher
High Throughput In Vivo Screens: Signature-tagged Mutagenesis
N West
P Sansonetti
CM Tang
Further Strategies for Signature-tagged Mutagenesis and the Application of Oligonucleotide Microarrays for the Quantification of DNA-tagged Strains
AV Karlyshev
N Dorrell
E Winzeler
BW Wren
IV Proteome Analysis
Advances in Bacterial Proteome Analysis
SJ Cordwell
Discovery of Protein-Protein Interaction Using Two-hybrid Systems
A Patel
KH Mellits
IF Connerton
V Applications of Microbial Genomics
Cloning the Metagenome: Culture-independent Access to the Diversity and Functions of the Uncultivated Microbial World
J Handelsman
M Liles
D Mann
C Riesenfeld
RM Goodman
Reverse Vaccinology: from Genome to Vaccine
JL Telford
M Pizza
G Grandi
R Rappuoli
Microbial Genomics for Antibiotic Target Discovery
F Fan
D McDevitt
VI Case Studies -- Bacteria
Helicobacter pylori Functional Genomics
KJ Guillemin
NR Salama
Streptomyces coelicolor A3(2): from Genome Sequence to Function
KF Chater
G Bucca
P Dyson
K Fowler
B Gust
P Herron
A Hesketh
G Hotchkiss
T Kieser
V Mersinias
CP Smith
Functional Analysis of the Bacillus subtilis Genome
CR Harwood
A Wipat
Z Pragai
VII Case Studies -- Parasites
Plasmodium falciparum DNA Microarrays and Interpretation of Data
AA Witney
RM Anthony
TR Jones
DJ Carucci
Functional Analysis of the Plasmodium falciparum Genome Using Transfection
AF Cowman
M Duraisingh
RA O'Donnell
T Triglia
BS Crabb
Chromosome Fragmentation as an Approach to Whole-genome Analysis in Trypanosomes
JM Kelly
S Obado
Index 407

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