Functional MRI An Introduction to Methods

by Jezzard, Peter; Matthews, Paul M.; Smith, Stephen M.

• ISBN13: 9780198527732
• ISBN10: 019852773X
• Format: Paperback
• Copyright: 2003-05-01
• Publisher: Oxford University Press

Summary

Brain scanning using magnetic resonance imaging has experienced exponential growth in the past decade, fast becoming the principal method for studying how the human brain operates by mapping its active processes. Functional MRI: An Introduction to Methods brings together some of the most distinguished researchers in this field to introduce the practices and principles behind these mapping techniques. This book covers fMRI as a whole and the growing demand for information concerning BOLD (blood oxygenation level dependent) contrast. The book divides into six sections. Part I is a scene-setter giving a broad overview of the area and the technique itself. Part II outlines the physical and physiological backdrop to fMRI, covering issues such as spatial and temporal resolution and quantitative measurement. The effectiveness of the scanner and design issues are debated in Part III. Part IV covers data preparation and analysis. This is followed by an outline of how the applications can be used in clinical practice and cognitive neuroscience (Part V). The final part discusses how fMRI and other neuroelectromagnetic functional mapping techniques can be integrated into one system.

Table of Contents

List of contributors	ix
Abbreviations	xi
I INTRODUCTION	1	(34)
An introduction to functional magnetic resonance imaging of the brain	3	(32)
Paul M. Matthews
II PHYSICS AND PHYSIOLOGY	35	(140)
Brain energy metabolism and the physiological basis of the haemodynamic response	37	(30)
Albert Gjedde
Principles of nuclear magnetic resonance and MRI	67	(26)
Peter Jezzard
Stuart Clare
Ultra-fast MRI	93	(16)
Richard A. Jones
Jason A. Brookes
Chrit T. W. Moonen
Hardware for functional MRI	109	(14)
Gary H. Glover
Selection of the optimal pulse sequence for functional MRI	123	(22)
Peter A. Bandettini
Spatial and temporal resolution in fMRI	145	(14)
Ravi S. Menon
Bradley G. Goodyear
Quantitative measurement using fMRI	159	(16)
Richard D. Hoge
G. Bruce Pike
III EXPERIMENTAL DESIGN	175	(38)
Effective paradigm design	177	(20)
David I. Donaldson
Randy L. Buckner
The scanner as a psychophysical laboratory	197	(16)
Robert Savoy
IV ANALYSIS OF FUNCTIONAL IMAGING DATA	213	(96)
Overview of fMRI analysis	215	(14)
Stephen M. Smith
Preparing fMRI data for statistical analysis	229	(14)
Stephen M. Smith
Head motion and its correction	243	(8)
Mick J. Brammer
Statistical analysis of activation images	251	(20)
Keith J. Worsley
Registration, brain atlases and cortical flattening	271	(24)
Mark Jenkinson
Extracting brain connectivity	295	(14)
Christian Buchel
Karl Friston
V fMRI APPLICATIONS	309	(42)
fMRI: applications in cognitive neuroscience	311	(18)
Adrian M. Owen
Russell Epstein
Ingrid S. Johnsrude
Clinical applications of mapping neurocognitive processes in the human brain with functional MRI	329	(22)
Keith R. Thulborn
Antonio Gisbert
VI INTEGRATING TECHNOLOGIES	351	(32)
Dynamic functional neuroimaging integrating multiple modalities	353	(30)
John S. George
David M. Schmidt
David M. Rector
Chris Wood
Index	383