Functional Tissue Engineering

by Guilak, Farshid; Butler, David L.; Goldstein, Steven A.; Mooney, David J.

• ISBN13: 9780387955537
• ISBN10: 0387955534
• Format: Hardcover
• Copyright: 2003-08-01
• Publisher: Springer Nature

Summary

Tissue engineering is an exciting new field at the interface of engineering and biology that uses implanted cells, scaffolds, DNA, proteins, protein fragments, and inductive molecules to repair or replace injured or diseased tissues and organs. Functional Tissue Engineering marks the tremendous progress in biological and biomaterials aspects of this field that have been accomplished to date. Functional tissue engineering represents a relevant and exciting new discipline in the field of tissue engineering. Readers will get an overview designed to increase awareness among tissue engineers about the importance of restoring biomechanical function in the development of living tissue substitutes. Further, the chapter authors identify the critical structural and mechanical requirements needed for each construct and provide a framework for the development of functional criteria in the design, manufacture, and optimization of tissue-engineered constructs. Garnering the expertise of a select group of biomedical engineers, biologists, and clinicians, Functional Tissue Engineering is a necessary resource for students, investigators, and clinicians engaged in this dynamic and exciting area. Book jacket.

Table of Contents

Preface	v
Contributors	xiii
Part I: The Functional Properties of Native Tissues	1	(84)
1. How Does Nature Build a Tissue?	3	(14)
Stephen C. Cowin
2. Ligament Healing: Present Status and the Future of Functional Tissue Engineering	17	(18)
Savio L.-Y. Woo, Steven D. Abramovich, John C. Loh, Volker Musahl, and James H.-C. Wang
3. Native Properties of Cardiovascular Tissues: Guidelines for Functional Tissue Engineering	35	(11)
Jay D. Hamphrey
4. Functional Properties of Native Articular Cartilage	46	(23)
Gerard A. Ateshian and Clark T. Hung
5. Excitability and Contractility of Skeletal Muscle: Measurements and Interpretations	69	(16)
John A. Faulkner and Robert G. Dennis
Part II. Functional Requirements of Engineered Tissues	85	(42)
6. Functional Requirements for the Engineering of a Blood Vessel Substitute	87	(9)
Robert M. Nerem and Jan P. Stegemann
7. In Vivo Force and Strain of Tendon, Ligament, and Capsule	96	(10)
Kai-Nan An
8. Requirements for Biological Replacement of the Articular Cartilage at the Knee Joint	106	(11)
Thomas Andriacchi
9. Functional Requirements: Cartilage	117	(10)
Jack L. Lewis
Part III: Design Parameters for Tissue Engineering	127	(84)
10. Design Parameters for Functional Tissue Engineering	129	(10)
Arnold I. Caplan
11. Tissue Engineering a Heart: Critical Issues	139	(7)
Michael V. Sefton and Robert Akins
12. Design Parameters for Engineering Bone Regeneration	146	(16)
Robert E. Guldberg and Angel O. Duty
13. Tissue Engineering of Bone: The Potential Uses of Gene Therapy for Difficult Bone Loss Problems	162	(16)
Brett Peterson and Jay R. Lieberman
14. Engineered Skeletal Muscle: Functional Tissues, Organs, and Interfaces	178	(16)
Robert G. Dennis
15. Bioengineering the Growth of Articular Cartilage	194	(17)
Stephen M. Klisch, Michael A. DiMicco, Anne Hoger, and Robert L. Sah
Part IV. Assessment of Function in Engineered Tissues	211	(64)
16. Functional Tissue Engineering: Assessment of Function in Tendon and Ligament Repair	213	(14)
David L. Butler, Matthew Dressler, and Hani Awad
17. The Role of Mechanical Forces in Tissue Engineering of Articular Cartilage	227	(16)
J.C.Y Hu and K.A. Athanasiou
18. Biomechanics of Native and Engineered Heart Valves Tissues	243	(15)
Michael S. Sacks
19. Assessment of Function in Tissue-Engineered Vascular Grafts	258	(10)
David N. Ka and Hai-Chan Han
20. Assessment of the Performance of Engineered Tissues in Humans Requires the Development of Highly Sensitive and Quantitative Noninvasive Outcome Measures	268	(7)
R.J. O'Keefe, S. Jotterman, E.M. Schwarz, J.M. Looney, G.S. Seo, J. Tamez-Pena, A. Boyd, S. Bukata, J. Monu, and K. Parker
Part V: Cell-Matrix Interactions in Functional Tissue Engineering	275	(60)
21. Functional Tissue Engineering and the Role of Biomechanical Signaling in articular Cartilage Repair	277	(14)
Farshid Guilak and Lori A. Seton
22. Regulation of Cellular Response to Mechanical Signals by Matrix Design	291	(14)
Craig A. Simmons and David J. Mooney
23. Artificial Soft Tissue Fabrication from Cell-Contracted Biopolymers	305	(13)
Robert T. Tranquillo and Brett C. Isenberg
24. Cytomechanics: Signaling to Mechanical Load in Connective Tissue Cells and Role in Tissue Engineering	318	(17)
Albert J. Banes, Michelle Wall, Joanne Gravin, and Joanne Archambault
Part VI: Bioreactors and the Role of Biophysical Stimuli in Tissue Engineering	335	(58)
25. The Role of Biomechanics in Analysis of Cardiovascular Diseases: Regulation of the Fluid Shear Response by Inflammatory Mediators	337	(10)
Geert W. Schmid-Schonbein and Shunichi Fukuda
26. A Full Spectrum of Functional Tissue-engineered Blood Vessels: From Macroscopic to Microscopic	347	(13)
E.A. Auger, G. Grenier, M. Remy-Zolghadri, and L. Germain
27. Engineering Functional Cartilage and Cardiac Tissue: In Vitro Culture Parameters	360	(17)
Lisa A. Freed, Maria A. Rupnick, Dirk Schaefer, and Gordana Vunjak-Novakovic
28. Tissue Engineering Skeletal Muscle	377	(16)
Paul E. Kosnik, Robert G. Dennis, and Herman H. Vandenburgh
Part VII: Regulatory and Clinical Issues in Tissue Engineering	393	(12)
29. From Concept Toward the Clinic: Preclinical Evaluation of Tissue-Engineered Constructs	395	(5)
Steven A. Goldstein
30. Trends in the FDA	400	(5)
Edith Richmond Schwartz
Index	405