Fundamentals of Analytical Toxicology

by Robert J. Flanagan (King's College Hospital NHS Foundation Trust, London, UK); Andrew A. Taylor (Royal Surrey County Hospital, UK); Ian D. Watson (Aintree Hospitals, Liverpool, UK); Robin Whelpton (Queen Mary, University of London, UK)

• ISBN13: 9780470516287
• ISBN10: 0470516283
• Format: eBook
• Copyright: 2008-04-01
• Publisher: Wiley-Interscience

Summary

The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens.After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electro-phoresis, mass spectrometry, and immunoassay - are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results. A clearly written, practical, integrated approach to the basics of analytical toxicology. Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications. Assumes only a basic knowledge of analytical chemistry. An accompanying website provides additional material and links to related sites.Written by an experienced team of authors, Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development.Praise from the reviews:"Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard. Understanding of the text is enhanced by the use of many illustrations. Specifications, guidelines, and methods are highlighted in grey background "Boxes". The many and up to date literature references in each chapter demonstrate the authors' thorough work and permit easy access to deeper information. Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader." GTFCh Bulletin "Toxichem + Krimtech", May 2008 (translated, original review in German)"Many toxicologists will add this important reference to their libraries because it competently fills a need at an acceptable cost." International Journal of Toxicology, September 2008

Table of Contents

Preface

Health and Safety

Nomenclature, Symbols and Conventions

Amount Concentration and Mass Concentration

Acknowledgements

List of Abbreviations

Analytical Toxicology: Overview

Sample Collection, Transport, and Storage

Sample Preparation

Colour Tests, and Spectrophotometric and Luminescence techniques

Introduction to Chromatography and Capillary Electrophoresis

Thin-Layer Chromatography

Gas Chromatography

High-Performance Liquid Chromatography

Capillary Electrophoretic Techniques

Mass Spectrometry

Trace Elements and Toxic Metals

Immunoassays and Enzyme-Based Assays

Toxicology Testing at the Point of care

Basic Laboratory Operations

Absorption, Distribution, Metabolism and Excretion of Xenobiotic Compounds

Pharmacokinetics

Clinical Interpretation of Analytical Results

Index

Table of Contents provided by Publisher. All Rights Reserved.