Fundamentals Of Asymmetric Catalysis

by Walsh, Patrick J.; Kozlowski, Marisa C.

• ISBN13: 9781891389542
• ISBN10: 1891389548
• Format: Hardcover
• Copyright: 2008-09-20
• Publisher: Univ Science Books

Summary

"The field of asymmetric catalysis plays an increasingly large role in chemical synthesis as the demand for single-enantiomer starting materials, intermediates, and products rises. This book describes the essential aspects of enantioselective catalysis in a clear, logical fashion, with chapters organized by concept rather than by reaction type. Each concept is supported by carefully selected examples to give the reader broad exposure to a wide range of catalysts, reactions, and reaction mechanisms." "This book is designed to introduce advanced undergraduate or graduate chemistry students to asymmetric catalysis. It can be used as the primary text in a course on this topic, or as a reference by researchers who wish to increase their understanding. It is also intended for synthetic chemists who wish to increase their likelihood for success when faced with the prospect of using asymmetric catalysts."--BOOK JACKET.

Author Biography

Marisa Kozlowski is a Professor of Chemistry at University of Pennsylvania. Patrick J. Walsh is a Professor of Chemistry at University of Pennsylvania.

Table of Contents

Introduction to Fundamentals of Asymmetric Catalysis
Modes of Asymmetric Induction	p. 1
Lewis Acid and Lewis Base Catalysis	p. 31
Beyond Lewis Acid and Lewis Base Catalyzed Activation	p. 65
Asymmetric Induction in Enantioselective Catalysis	p. 114
Nonclassical Catalyst Substrate Interactions	p. 165
Chiral Poisoning, Chiral Activation, and Screening Achiral Ligands	p. 191
Kinetic Resolution	p. 231
Parallel Kinetic Resolution	p. 255
Dynamic Kinetic Resolution and Dynamic Kinetic Asymmetric Transformations	p. 271
Desymmetrization Reactions	p. 297
Nonlinear Effects, Autocatalysis, and Autoinduction	p. 330
Bifunctional, Dual, and Multifunctional Catalyst Systems	p. 375
Asymmetric Catalysis with Enantiopure Substrates: Double Diastereoselection	p. 427
Multistep Asymmetric Catalysis	p. 455
Supported Chiral Catalysts	p. 495
Applications of Asymmetric Catalysis in Synthesis	p. 549
Terms & Enantioselective Processes in Asymmetric Catalysis	p. 577
Index	p. 637
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