Fundamentals of Enzyme Kinetics

by Cornish-Bowden, Athel

• ISBN13: 9783527330744
• ISBN10: 3527330747
• Edition: 4th
• Format: Paperback
• Copyright: 2012-02-27
• Publisher: Wiley-Blackwell

Summary

Now in its fourth edition, this textbook is one of the few titles worldwide to cover enzyme kinetics in its entire scope and the only one to include its implications for bioinformatics and systems biology. Multi-enzyme complexes and cooperativity are therefore treated in more detail than in any other textbook on the market. The respected and well known author is one of the most experienced researchers into the topic and writes with outstanding style and didactic clarity. As with the previous editions, he presents here steady-state kinetics and fast reactions, supplementing each chapter with problems and solutions. For the first time, this edition features color illustrations and a companion website.

Author Biography

Athel Cornish-Bowden is, since 2009, Directeur de Recherche ?m?rite at the CNRS in Marseilles. He studied at the University of Oxford, and after post-doctoral research at the University of California, Berkeley, he spent the early part of his career at the University of Birmingham as Lecturer and later Senior Lecturer in the Department of Biochemistry. In 1987 he moved to France as Directeur de Recherche (1?re classe) in the CNRS in Marseilles. He has authored more than 200 scientific publications, including several books as author and as editor. He has served on the editorial boards of several journals.

Table of Contents

Basic Principles of Chemical Kinetics
Introduction to Enzyme Kinetics
"Alternative" Enzymes
Practical Aspects of Kinetics
Deriving Steady-state Rate Equations
Reversible Inhibition and Activation
Tight-binding and Irreversible Inhibitors
Reactions of More than One Substrate
Use of Isotopes for Studying Enzyme Mechanisms
Effect of pH on Enzyme Activity
Temperature Effects on Enzyme Activity
Regulation of Enzyme Activity
Multienzyme Systems
Fast Reactions
Estimation of Kinetic Constants
Standards for Reporting Enzymology Data
Solutions and Notes to Problems
Index