GABA and Sleep

by Monti, Jaime M.; Pandi-Perumal, S. R.; Mohler, Hanns

• ISBN13: 9783034602259
• ISBN10: 3034602251
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-09-29
• Publisher: Springer Verlag

Summary

GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. The GABA system is, therefore, of prime clinical relevance for the therapy of insomnia. The focus of this volume is on the neuropsychopharmacology and the clinical impact of the GABA system in regulating sleep and wakefulness. It presents molecular, neuropharmacological, systems-biological and clinical approaches to the understanding of the mechanism of action of GABA and GABAergic drugs. It also explores the role of GABA in the basic drives that affect sleep, and the influences that adapt sleep and wakefulness to external events.

Table of Contents

Basic Physiology and Pharmacology
Physiology and Pharmacology of the GABA System: Focus on GABA Receptors	p. 3
Development of Subtype-Selective GABAA Receptor Compounds for the Treatment of Anxiety, Sleep Disorders and Epilepsy	p. 25
Distribution of GABAA Receptor Subunits in the Human Brain	p. 73
Pharmacokinetic Determinants of the Clinical Effects of Benzodiazepine Agonist Hypnotics	p. 95
Sleep Science and Circuitry
Sleep and Its Modulation by Substances That Affect GABAA Receptor Function	p. 121
Subcortical Neuromodulation of Feedforward and Feedback Inhibitory Microcircuits by the Reticular Activating System	p. 147
Function of GABAB and ¿-Containing GABAA Receptors (GABAC Receptors) in the Regulation of Basic and Higher Integrated Sleep-Waking Processes	p. 169
Interactions Between GABAergic and Serotonergic Processes in the Dorsal Raphe Nucleus in the Control of REM Sleep and Wakefulness	p. 189
GABA-ergic Modulation of Pontine Cholinergic and Noradrenergic Neurons for REM Sleep Generation	p. 199
Involvement of GABAergic Mechanisms in the Laterodorsal and Pedunculopontine Tegmental Nuclei (LDT-PPT) in the Promotion of REM Sleep	p. 213
GABAergic Mechanisms in the Ventral Oral Pontine Tegmentum: The REM Sleep-Induction Site - in the Modulation of Sleep-Wake States	p. 233
The Role of GABAergic Modulation of Mesopontine Cholinergic Neurotransmission in Rapid Eye Movement (REM) Sleep	p. 253
Melatonin and Sleep: Possible Involvement of GABAergic Mechanisms	p. 279
GABA Involvement in the Circadian Regulation of Sleep	p. 303
Hypnotics
Pathophysiology of Sleep Disorders	p. 325
Insomnia: Differential Diagnosis and Current Treatment Approach	p. 363
Zolpidem in the Treatment of Adult and Elderly Primary Insomnia Patients	p. 383
Efficacy and Safety of Zopiclone and Eszopiclone in the Treatment of Primary and Comorbid Insomnia	p. 413
Indiplon	p. 453
Polysomnographic and Clinical Assessment of Zaleplon for the Treatment of Primary Insomnia	p. 465
Index	p. 481
Table of Contents provided by Ingram. All Rights Reserved.