Galectins

by Klyosov, Anatole A.; Witczak, Zbigniew J.; Platt, David

• ISBN13: 9780470373187
• ISBN10: 0470373180
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-07-15
• Publisher: Wiley

Summary

This is the first book specifically on galectinsa challenging and promising area in medical biochemistry and drug design. After an introduction to galectins, the book covers their structure and functions, ligand specificity, and molecular mechanisms of action, along with the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity. Then it covers the effect of galectins on cell migration, angiogenesis, and chemoresistance and describes new approaches to designing galectin inhibitors. This is a core reference for chemists, biochemists, pharmacologists, biologists and others interested in this emerging field.

Author Biography

Anatole A. Klyosov, PhD, is Chief Scientist and cofounder of Pro-Pharma-ceuticals, Inc. He has published more than 290 peer-reviewed articles in scientific journals; authored and edited books on enzymes, carbohydrates, and biotechnology, including Wood-Plastic Composites (Wiley); and holds thirty-nine patents.

Zbigniew J. Witczak, PhD, has extensive industrial and academic experience in carbohydrates. He has published more than ninety research papers and holds six patents in the fields of carbohydrate, medicinal, and biological chemistry. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award of the ACS Division of Carbohydrate Chemistry for his outstanding research contribution to carbohydrate chemistry and service to the division.

David Platt, PhD, is Chief Executive Officer and cofounder of Pro-Pharmaceuticals, Inc. He has published peer-reviewed articles and holds many patents, primarily in the field of carbohydrate chemistry. Dr. Klyosov, Dr. Witczak, and Dr. Platt coedited the ACS symposium book Carbohydrate Drug Design.

Table of Contents

Preface	p. vii
Contributors	p. ix
Stumbling on Galectins	p. 1
Galectins and Their Functions in Plain Language	p. 9
Understanding Galectin Structure-Function Relationships to Design Effective Antagonists	p. 33
Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design	p. 71
Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and Their Roles in Pre-mRNA Splicing	p. 87
Galectins in Regulation of Inflammation and Immunity	p. 97
Galectins as Danger Signals in Host-Pathogen and Host-Tumor Interactions: New Members of the Growing Group of "Alarmins"?	p. 115
The Role of Galectins in Organ Fibrosis	p. 147
Galecitin-1, Cancer Cell Migration, Angiogenesis, and Chemoresistance	p. 157
Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia	p. 193
Galectins in Malignant Gliomas: Expression, Functions, and Possible Therapeutic Options	p. 223
Food-Related Carbohydrate Ligands for Galectins	p. 235
Index	p. 271
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