Galectins

by Editor: Anatole A. Klyosov; Editor: Zbigniew J. Witczak; Editor: David Platt

• ISBN13: 9780470377789
• ISBN10: 047037778X
• Format: eBook
• Copyright: 2008-10-01
• Publisher: Wiley

Summary

The comprehensive guide to the current understanding of galectins and their promising potential in drug design This is the first book focusing on galectins. It was inspired by topics discussed at the symposium "Galectins: Structures, Functions, and Therapeutic Targets" that was a part of the 234th American Chemical Society meeting in 2007. To help chemists, biochemists, and others understand the challenges inherent in the study of galectins and build on recent advances in the field, the editors have compiled articles from leading experts on galectins and their biomedical applications. Galectins includes: * An overview of early galectin research * An explanation of the nature of galectins * A discussion of the structure and functions of galectins, their ligand specificity and molecular mechanisms of action, and the localization of galectins in the cell * An exploration of the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity * A discussion of the effect of galectins on cell migration, angiogenesis, and chemoresistance * An introduction to new approaches to designing galectin inhibitors This is the premier reference on galectins for organic, medicinal, carbohydrate, and pharmaceutical chemists, biochemists, molecular and cell biologists, pharmacologists, cancer researchers, and graduate-level students in these disciplines, as well as clinicians and drug developers.

Table of Contents

Preface

Stumbling on Galectins

Galectins and their Functions in Plain Language

Understanding Galectin Structure-Function Relationships to Design Effective Antagonists

Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design

Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and their Roles in pre-mRNA Splicing

Galectins in Regulation of Inflammation and Immunity

Galectins as Danger Signals in Host-Pathogen and Host-Tumor Interactions: New Members of the Growing Group of "Alarmins"

The Role of Galectins in Organ Fibrosis

Galectin-1, Cancer Cell Migration, Angiogenesis and Chemoresistance

Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia

Galectins in Malignant Gliomas: Expression, Functions and Possible Therapeutic Options

Food-Related Carbohydrate Ligands for Galectins

Index

Table of Contents provided by Publisher. All Rights Reserved.