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9780203300992

Gamma-hydroxybutyrate: Molecular, Functional and Clinical Aspects

by Cash, Christopher D.
  • ISBN13:

    9780203300992

  • ISBN10:

    0203300998

  • Copyright: 2004-02-03
  • Publisher: Taylor & Francis

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Summary

Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. Gamma-Hydroxybutyrate: Pharmacological and Functional Aspects brings together the combined expertise of many of the leading authorities on the biochemistry, physiology, and pharmacology of GHB in the central nervous system. Each chapter is an in-depth review of the field and the book itself will appeal to all neurobiologists interested in neurotransmitter mechanisms, as well as to clinicians and other health-care workers interested in this fascinating chemical.

Table of Contents

Metabolism and Distribution of Gamma-Hydroxybutyrate in the Brain
The Gamma-hydroxybutyrate Receptor in the Brain
Part of the Pharmacological Actions of Gamma-hydroxybutyrate Are Mediated by GABAB Receptors
Membrane Transport of Gamma-hydroxybutyrate
Action of Gamma-hydroxybutyrate on Neuronal Excitability and Underlying Membrane Conductances
Regulation of Central Dopamine by Gamma-hydroxybutyrate
Effects of Gamma-hydroxybutyrate on Sleep
Gamma-hydroxybutyrate and Absence Seizure Activity
Behavioral Pharmacology of Gamma-hydroxybutyrate
Therapeutic Uses of Gamma-hydroxybutyrate
Abuse Potential and Toxicology of Gamma-hydroxybutyrate
4-Hydroxybutyric Aciduria
Gamma-Hydroxybutyrate and Oxidative Stress
The Role of Gamma-hydroxybutyrate in Brain function
Table of Contents provided by Publisher. All Rights Reserved.

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