Gastrointestinal Oncology

by Abbruzzese, James L.; Evans, Douglas B.; Willett, Christopher G.; Fenoglio-Preiser, Cecilia

• ISBN13: 9780195133721
• ISBN10: 0195133722
• Format: Hardcover
• Copyright: 2003-10-23
• Publisher: Oxford University Press

Summary

In 74 chapters, Gastrointestinal Oncology brings together a diverse group of specialists to provide the most authoritative, up-to-date and encyclopedic volume currently available on the subject. The first part of this text introduces a series of concepts and topics taht are important togastrointestinal malignancies in general. These topics include epidemiologic principles, prevention, screening, familial GI cancers, developmental and molecular biology, pathobiology, general therapeutic principles, emerging therapies, and palliative care. The second part of the book covers eachof the specific cancers affecting the human gastrointestinal tract. These chapters are introduced by state of the art discussions outlining our current understanding of the pathobiology and molecular biology relevant to each cancer. Subsequent sections describe the multidisciplinary management ofspecific clinical situations. By organizing the treatment-related chapters around clinical scenarios, the reader will readily find the information necessary to effectively manage the complex clinical situations encountered by patients with gastrointestinal malignancies.

Table of Contents

Contributors	p. xi
General Principles
Epidemiological Principles for the Study of Gastrointestinal Cancers	p. 3
Prevention and Screening Principles Relevant to Gastrointestinal Malignancies	p. 9
The Role of Inheritance in the Diagnosis and Management of Gastrointestinal Malignancies	p. 37
Developmental Biology of the Gastrointestinal Tract	p. 44
General Pathobiological Features of Gastrointestinal Neoplasia	p. 69
Therapeutic Principles of Gastrointestinal Neoplasia: Surgery	p. 80
Therapeutic Principles of Gastrointestinal Neoplasia: Radiation Oncology	p. 88
Therapeutic Principles of Gastrointestinal Neoplasia: Chemotherapy	p. 91
Therapeutic Principles of Gastrointestinal Neoplasia: Emerging Therapies: Vaccines	p. 102
Therapeutic Principles of Gastrointestinal Neoplasia: Emerging Therapies: Gene Therapy	p. 112
Therapeutic Principles of Gastrointestinal Neoplasia: Emerging Therapies: Antiangiogenic and Antimetastatic Agents	p. 121
Management of Specific Neoplasms
Cancer of the Esophagus
Epidemiology and Molecular Epidemiology of Esophageal Cancer	p. 129
Molecular Biology of Esophageal Cancer	p. 155
Pathology and Natural History of Esophageal Cancer	p. 167
Clinical Aspects and Management of Esophageal Carcinoma: Diagnostic and Staging Procedures	p. 182
Clinical Aspects and Management of Esophageal Carcinoma: Management Options: Potentially Resectable Esophageal Cancer	p. 190
Clinical Aspects and Management of Esophageal Carcinoma: Management Options: Locally Advanced Unresectable Esophageal Cancer	p. 218
Clinical Aspects and Management of Metastatic Carcinoma of the Esophagus and Gastroesophageal Junction	p. 227
Barrett's Esophagus: Molecular Biology and Pathobiology	p. 231
Barrett's Esophagus: Clinical Aspects and Management	p. 241
Cancer of the Stomach
Epidemiology and Molecular Epidemiology of Gastric Cancer	p. 257
Molecular Biology of Gastric Cancer	p. 268
Pathology and Natural History of Gastric Cancer	p. 281
Clinical Aspects and Management of Gastric Carcinoma: Diagnostic and Staging Procedures	p. 294
Clinical Aspects and Management of Gastric Carcinoma: Management Options: Potentially Resectable Gastric Cancer	p. 302
Locally Advanced Unresectable Gastric Cancer	p. 311
Management Options: Metastatic Gastric Carcinoma	p. 316
Cancer of the Pancreas
Epidemiology and Molecular Epidemiology of Pancreatic Cancer	p. 329
Molecular Biology of Pancreatic Adenocarcinoma	p. 336
Pathology and Natural History of Pancreatic Cancer	p. 344
Clinical Aspects and Management of Pancreatic Adenocarcinoma: Diagnostic and Staging Procedures	p. 355
Clinical Aspects and Management of Pancreatic Adenocarcinoma: Management Options: Potentially Resectable Pancreatic Cancer	p. 363
Clinical Aspects and Management of Pancreatic Adenocarcinoma: Management Options: Locally Advanced Unresectable Pancreatic Cancer	p. 377
Clinical Aspects and Management of Metastatic Pancreatic Cancer	p. 386
Cancer of the Bile Ducts and Gallbladder
Epidemiology, Molecular Epidemiology, and Biomarkers of Biliary Tract Cancers	p. 401
Molecular Biology of Cholangiocarcinoma and Gallbladder Carcinoma	p. 413
Pathology and Natural History of Cholangiocarcinoma and Gallbladder Carcinoma	p. 420
Clinical Aspects and Management of Cholangiocarcinoma and Gallbladder Carcinoma: Diagnostic and Staging Procedures	p. 428
Clinical Aspects and Management of Cholangiocarcinoma and Gallbladder Carcinoma: Potentially Resectable Gallbladder Carcinoma or Cholangiocarcinoma	p. 436
Clinical Aspects and Management of Cholangiocarcinoma and Gallbladder Carcinoma: Management Options: Unresectable Gallbladder Carcinoma and Cholangiocarcinoma	p. 454
Hepatocellular Cancer
Epidemiology and Molecular Epidemiology of Hepatocellular Cancer	p. 463
Molecular Biology of Hepatocellular Cancer	p. 471
Pathology and Natural History of Hepatocellular Carcinoma	p. 507
Clinical Aspects and Management of Hepatocellular Cancer: Diagnostic and Staging Procedures	p. 515
Clinical Aspects and Management of Hepatocellular Cancer: Management Options: Potentially Resectable Hepatocellular Carcinoma	p. 522
Clinical Aspects and Management of Hepatocellular Cancer: Management Options: Metastatic Hepatocellular Carcinoma	p. 529
Cancer of the Small Bowel and Appendix
Epidemiology, Molecular Epidemiology, and Molecular Biology of Small Bowel and Appendiceal Adenocarcinomas	p. 539
Pathology and Natural History of Small Bowel and Appendiceal Cancers	p. 549
Clinical Aspects and Management of Small Bowel and Appendiceal Cancers: Diagnostic and Staging Procedures	p. 560
Clinical Aspects and Management of Small Bowel and Appendiceal Cancers: Management Options: Potentially Resectable Small Bowel and Appendiceal Carcinomas	p. 569
Clinical Aspects and Management of Small Bowel and Appendiceal Cancers: Management Options: Unresectable, Locally Advanced, and Metastatic Small Bowel and Appendiceal Carcinomas	p. 585
Cancer of the Colorectum
Epidemiology and Prevention of Colorectal Cancer	p. 593
Molecular Biology of Colorectal Cancer	p. 635
Familial Colorectal Cancer Syndromes	p. 645
Pathology and Natural History of Colorectal Cancer	p. 665
Clinical Aspects and Management of Colon Adenocarcinoma: Diagnostic and Staging Procedures	p. 676
Clinical Aspects and Management of Colon Adenocarcinoma: Management of Local and Locoregional Colon Cancer	p. 682
Clinical Aspects and Management of Rectal Adenocarcinoma: Diagnostic and Staging Procedures	p. 694
Clinical Aspects and Management of Rectal Adenocarcinoma: Management Options: Resectable Rectal Carcinoma	p. 702
Clinical Aspects and Management of Rectal Adenocarcinoma: Management Options: Unresectable Rectal Carcinoma	p. 714
Management Options: Metastatic Colorectal Carcinoma	p. 728
Cancer of the Anus
Pathology, Molecular Biology, and Natural History of Anal Cancer	p. 749
Clinical Aspects and Management of Anal Cancer	p. 760
Neuroendocrine Cancers of the Gastrointestinal Tract
Management of Neuroendocrine Cancers of the Gastrointestinal Tract: Carcinoid Tumors	p. 773
Management of Neuroendocrine Cancers of the Gastrointestinal Tract: Islet Cell Carcinoma of the Pancreas and Other Neuroendocrine Carcinomas	p. 780
Lymphomas of the Gastrointestinal Tract
Mucosa-Associated Lymphoid Tissue Lymphomas	p. 803
Low- and High-Grade Lymphomas	p. 812
Sarcomas of the Gastrointestinal Tract
Epidemiology, Pathology, Molecular Biology, and Natural History of Gastrointestinal Sarcomas	p. 821
Clinical Aspects and Management of Gastrointestinal Sarcomas: Management Options: Potentially Resectable Gastrointestinal Sarcomas	p. 826
Clinical Aspects and Management of Gastrointestinal Sarcomas: Management Options: Unresectable or Metastatic Gastrointestinal Sarcomas	p. 834
Palliative Care of Patients With Gastrointestinal Malignancy
Nutritional Support of Patients with Gastrointestinal Malignancies	p. 841
Management of Obstructive Complications of Upper Gastrointestinal Tract: Esophagus, Stomach, and Biliary Tree	p. 866
Management of Obstructive Complications of Lower Gastrointestinal Tract: Colon and Rectum	p. 875
Pain Management	p. 881
Index	p. 893
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