Gastrointestinal Pharmacology and Therapeutics

by Friedman, Gerald; Jacobson, Eugene D., M.D.; McCallum, Richard W.

• ISBN13: 9780397516254
• ISBN10: 0397516258
• Format: Hardcover
• Copyright: 1997-01-01
• Publisher: Lippincott Williams & Wilkins

Summary

Mount Sinai School of Medicine, New York City. Text on the pharmacology and therapeutics of digestive disease, with emphasis on the underlying pathophysiology of disorders that respond to pharmacologic intervention. 90 contributors, 86 U.S. DNLM: Digestive System Diseases - drug therapy.

Table of Contents

I Fundamentals of Gastrointestinal Pharmacology
Fundamentals of Gastrointestinal Pharmacology	1	(20)
Thomas F. Burks
II Acid-Related Disorders
Helicobacter pylori-Induced Gastritis, Ulceration, and Neoplasia Epidemiology, Pathophysiology, and Therapeutics	21	(10)
Peter Malfertheiner
James Freston
Gastroesophageal Reflux Disease	31	(14)
Peter J. Kahrilis
Gastric and Duodenal Ulcers	45	(10)
Colin W. Howden
Drug-Induced Ulcerogenesis	55	(10)
Naurang M. Agrawal
Esam Z. Dajani
Management of Acid Hypersecretion in Patients with Zollinger-Ellison Syndrome	65	(10)
Paul N. Maton
Stress Ulcer Prophylaxis A Systematic Review and Evidence-Based Recommendations	75	(4)
Deborah J. Cook
III Motility Disorders
Pathophysiology of Gastrointestinal Motility Disorders	79	(10)
Richard W. McCallum
Principles of Gut Pharmacology	89	(8)
Richard W. McCallum
Pharmacotherapy of the Esophageal Motor Disorders	97	(6)
Ravinder K. Mittal
Therapeutic-Pharmacologic Approach to Delayed Gastric Emptying	103	(10)
Richard W. McCallum
Chronic Intestinal Pseudo-Obstruction	113	(14)
G. Nicholas Verne
Charles A. Sninsky
IV Functional Gastrointestinal Disorders
Pharmacologic Therapy of Irritable Bowel Syndrome	127	(6)
Marvin M. Schuster
Functional Gastrointestinal Disorders Chronic Pain Management	133	(14)
Ivan Barofsky
V Pain Management
Gastrointestinal Pain	147	(6)
Charles B. Stacy
VI Gastrointestinal Water Flux
The Pathophysiology of Diarrhea and Constipation The Role of Intestinal Water and Electrolyte Flux	153	(6)
Eugene B. Chang
Cathartics, Laxatives, and Lavage Solutions	159	(16)
Lawrence R. Schiller
Antidiarrheal Therapy	175	(18)
Richard N. Fedorak
VII Infections of the Gut
Pathophysiology of Gastrointestinal Infections Host Defenses Versus Microbial Virulence Traits	193	(8)
Nathan M. Thielman
Richard L. Guerrant
Diagnosis and Pharmacotherapy of Infections Esophagitis	201	(14)
Jonathan P. Moorman
Pharmacology of Small Bowel Infections Pathogens and Therapeutic Approaches	215	(34)
Richard N. Greenberg
Selin Zeytin
Kenneth J. Kortas
Infections of the Colon	249	(18)
Theodore S. Steiner
Richard L. Guerrant
VIII Acquired Immunodeficiency Syndrome and the Gut
Acquired Immunodeficiency Syndrome and the Gut Pathophysiology	267	(10)
Lee M. Oberman
Donald P. Kotler
Esophageal Disease in Acquired Immunodeficiency Syndrome	277	(10)
Maurizio Bonacini
Loren Laine
The Stomach in Human Immunodeficiency Virus Disease	287	(8)
Gerond Lake-Bakaar
Small Bowel Disease	295	(14)
Ronald Fogel
Tamir Ben-Menachem
Colonic Disease in Acquired Immunodeficiency Syndrome	309	(18)
Michael A. Poles
Douglas T. Dieterich
Edward A. Lew
IX Acute and Chronic Noninfections Inflammatory States
Agents Commonly Used in the Treatment of Inflammatory Bowel Disease	327	(22)
James H. Reichheld
Mark A. Peppercorn
New Therapeutic Agents	349	(18)
Miguel D. Regueiro
Mark A. Peppercorn
Medical Management of Ulcerative Colitis and Other Colitis Syndromes	367	(8)
Alain Bitton
Mark A. Peppercorn
Medical Management of Crohn's Disease	375	(8)
Alain Bitton
Mark A. Peppercorn
X Pharmacologic Therapy of Hepatic Disorders
Hepatitis and	383	(18)
Gary L. Davis
Pathophysiology and Pharmacology of Cholestasis	401	(16)
Mitchell L. Schiffman
Douglas M. Heuman
Treatment of Chronic Cholestatic Liver Disease	417	(32)
George Dickstein
Marshall M. Kaplan
Pharmacology and Medical Management of Hepatic Cirrhosis and Fibrosis	449	(16)
Bahri M. Bilir
Nuray Bilir
Alcoholic Liver Disease	465	(24)
Charles S. Lieber
XI Biliary Pharmacology
Primary Sclerosing Cholangitis Pathogenesis and Therapy	489	(12)
Lee McHenry, Jr.
Amy Foxx-Orenstein
Mitchell L. Schiffman
Sphincter of Oddi Current Approaches	501	(12)
Wahid Y. Wassef
Alvin M. Zfass
Prevention and Medical Treatment of Gallstones	513	(14)
Douglas M. Heuman
Mitchell L. Schiffman
Identification and Management of the Hyperlipidemic Patient	527	(14)
R. T. Stravitz
W. M. Pandak
XII Pancreas
Pathophysiology of Acute Pancreatitis	541	(8)
Michael L. Steer
Inflammatory Mediators in Acute Pancreatitis	549	(10)
Heinrich Rinderknecht
Treatment of Acute Pancreatitis From Animal Models to Randomized Human Trials	559	(6)
Scott Tenner
Peter A. Banks
Pathophysiology of Chronic Pancreatitis	565	(6)
Subhash C. Gumber
Steven D. Freedman
Chronic Pancreatitis Pathophysiology and Treatment of Steatorrhea	571	(8)
Daisuke Koike
Eugene P. DiMagno
Chronic Pancreatitis Pathophysiology and Treatment of Pain	579	(6)
Amy Kusske
Howard A. Reber
XIII Pharmacology of Gastrointestinal Vasculature
The Pharmacology of Vasoconstriction	585	(12)
Eugene D. Jacobson
The Medical Therapy of Intestinal Ischemia	597	(6)
Joel S. Levine
XIV Special Issues
Nausea and Vomiting	603	(8)
Richard W. McCallum
Use of Gastrointestinal and Hepatic Drugs During Pregnancy and Lactation	611	(22)
Rajeev Nayar
James H. Lewis
Gastrointestinal Cancer	633	(10)
Lynn H. Ratner
Steven Gruenstein
Pediatric Concerns	643	(12)
Keith J. Benkov
Considerations in the Geriatric Patient	655	(14)
Lidia Pousada
Lawrence J. Brandt
Genetics and Gene Therapy for Gastrointestinal Diseases	669	(8)
Jayanta Roy Chowdhury
Namita Roy Chowdhury
George Y. Wu
XV Drug Assessment
The Drug Development Process An FDA Perspective	677	(16)
Robert Temple
Role of the Pharmaceutical Industry in Drug Development	693	(14)
Robert H. Palmer
Leanne C. Wagner
The Clinical Trials Process	707	(16)
Thomas Q. Garvey III
Larry R. Muenz
Development of Gastrointestinal Drugs for Over-the-Counter Indications	723	(20)
Mark A. Sirgo
Bernard Schachtel
The Economics of Drug Therapy	743	(16)
Ralph O Bischof
David B. Nash
James H. Lewis
Index	759