Gene Therapy in Inflammatory Diseases

by Evans, Christopher H.; Robbins, Paul D.

• ISBN13: 9783764358556
• ISBN10: 3764358556
• Format: Hardcover
• Copyright: 2000-03-01
• Publisher: Birkhauser

Summary

Gene therapy for inflammatory diseases is a new , burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the book describes the advances that have been made in applying them to arthritis, lupus, multiple sclerosis, diabetes, Sjogren's syndrome and transplantation.One chapter is devoted to discussing the first human clinical trials that apply gene therapy to the treatment of an inflammatory disease. As well as providing novel therapeutic approaches, gene therapy facilitates the development of new and improved animal models of disease; a chapter describing these advances is also included. As an up-to-date, timely book written by th

Table of Contents

List of contributors	vii
Preface	xi
Gene therapy for inflammatory diseases-basic concepts	1	(12)
Christopher H. Evans
Paul D. Robbins
Gene therapy for rheumatoid arthritis: preclinical studies	13	(22)
Sergei S. Makarov
Cartilage erosion in rheumatoid arthritis: studies in SCID mouse model	35	(18)
Thomas Pap
Ulf Muller-Ladner
Klaus M. Hummel
Renate E. Gay
Steffen Gay
Gene therapy for rheumatoid arthritis: clinical studies	53	(12)
Thomas S. Muzzonigro
Richard Kang
Julio Reinecke
Peter Wehling
Mary C. Wasko
James H. Herndon
Cytokine gene therapy of allergic airways inflammation	65	(18)
Alistair J. Ramsay
Simon P. Hogan
Paul S. Foster
Yelin Xiong
Gene therapy for inflammatory diseases of the salivary glands	83	(12)
Philip C. Fox
Brian C. O'Connell
Gene therapy for management of lupus: correction of Fas and Fas ligand-induced apoptosis in murine disease-therapeutic rationale and strategies	95	(24)
Huang-Ge Zhang
Martin Fleck
Hui-Chen Hsu
Carl K. Edwards III
Gene therapy for multiple sclerosis	119	(14)
Michael K. Shaw
Richard DalCanto
C. Garrison Fathman
Gene therapy for type I diabetes mellitus	133	(30)
Nick Giannoukakis
Massimo Trucco
Paul D. Robbins
Gene transfer to facilitate transplantation	163	(42)
Jonathan S. Bromberg
Lisa A. DeBruyne
Randall S. Sung
Lihui Qin
DNA vaccination as an anti-inflammatory strategy	205	(26)
Alexis paul Godillot
Michael Madaio
David B. Weiner
William V. Williams
Naked DNA as a gene delivery vehicle in inflammatory diseases	231	(10)
Masayuki Muyata
Yukio Sato
Reiji kasukawa
Animal models of arthritis generated by gene transfer	241	(15)
Steven C. Ghivizzani
Eric R. Lechman
Daniel Jaffurs
Zhibao Mi
Richard Kang
Thomas S. Muzzonigro
Christopher H. Evans
Paul D. Robbins
Index	256