The Genetic Basis of Common Diseases

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  • Edition: 2nd
  • Format: Hardcover
  • Copyright: 2002-10-17
  • Publisher: Oxford University Press

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Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult diseases, and we now have a better understanding of the molecular processes involved in genetic susceptibility and diseases mechanisms. The second edition fully incorporates these advances. The entire book has been updated and twelve new chapters have been added. Most of these chapters deal with diseases such as gallstones, osteoporosis, osteoarthritis, skin cancer, other common skin diseases, prostate cancer and migraine headaches that are seen by all physicians. Others address the genetic and molecular basis of spondylarthropathies, lupus, hemochromatosis, IgA deficiency, mental retardation, hearing loss, and the role of mitochondrial variation in adult diseases. Chapters on the evolution of human genetic disease and on animal models add important background on the omplexities of these diseases. Unique clinical applications of genetics to common diseases are covered in the additional new chapters on genetic counseling, pharmacogenetics, and the genetic consequences of modern therapeutics.

Table of Contents

Contributorsp. ix
Approach to Genetic Basis of Common Diseasesp. 3
Molecular Genetics of Common Diseasep. 18
Genetic Epidemiologic Methodsp. 39
Evolution of Human Genetic Diseasesp. 50
Animal Models of Complex Genetic Diseasep. 65
Genetic Counseling: History, Risk Assessment, Strategies, and Ethical Considerationsp. 87
Cardiopulmonary Diseases
Genetics of Coronary Atherosclerosisp. 105
Hypertensionp. 127
Chronic Obstructive Pulmonary Diseasep. 155
Immunologic and Infectious Diseases
Genetics of Human Susceptibility to Infectious Diseases: Progress and Prospectsp. 181
Genetics of Asthma and Bronchial Hyperresponsivenessp. 198
IgA Deficiency and Common Variable Immunodeficiencyp. 210
Gastrointestinal Disorders
Peptic Ulcer and Gastritisp. 229
Lactase Deficiency: Biological and Medical Aspects of the Adult Human Lactase Polymorphismp. 250
Inflammatory Bowel Diseasep. 266
Gallstonesp. 298
Chronic Liver Diseasep. 336
Hereditary Hemochromatosisp. 366
Gluten-Sensitive Enteropathyp. 382
Endocrine Disorders
Thyroid Diseasep. 397
Type 1 Diabetes Mellitusp. 431
Type 2 Diabetes Mellitusp. 457
Obesityp. 481
Genetics of Osteoporosisp. 510
Hyperuricemia and Goutp. 518
Genitourinary Disorders
Gynecologic Disordersp. 539
Infertility and Pregnancy Lossp. 554
Rheumatologic Diseases
Immunology and Immunogeneticsp. 573
Rheumatoid Arthritisp. 587
Seronegative Spondyloarthropathiesp. 604
Genetics of Systemic Lupus Erythematosusp. 612
Genetic Basis of Primary Osteoarthritisp. 629
Common Disorders of Connective Tissuep. 638
Gastrointestinal Cancerp. 649
Breast Cancerp. 670
Familial and Genetic Influences on Risk of Lung Cancerp. 700
Reproductive Organ Cancersp. 713
Skin Cancerp. 724
Prostate Cancerp. 738
Hematologic Cancerp. 749
Neuropsychiatric Disorders
Epilepsyp. 779
Multiple Sclerosisp. 805
Alzheimer's Diseasep. 818
Affective Disordersp. 831
Schizophreniap. 850
Alcoholismp. 876
Mental Retardationp. 914
Hereditary Hearing Lossp. 920
Migrainep. 935
Other Common Problems
Common Skin Diseasesp. 951
Genetic Modulation of Aging and Longevityp. 964
Mitochondrial Defects in Common Diseasesp. 975
Constitutional Chromosome Disorders in Adultsp. 989
Genetic Consequences of Modern Therapeutics: Iatrogenic Mutagenesisp. 1023
Pharmacogenetics, Ecogenetics, and Pharmacogenomicsp. 1033
Indexp. 1041
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