The Genetic Basis of Common Diseases

by King, Richard A.; Rotter, Jerome I.; Motulsky, Arno G.

• ISBN13: 9780195125825
• ISBN10: 0195125827
• Edition: 2nd
• Format: Hardcover
• Copyright: 2002-10-17
• Publisher: Oxford University Press

Summary

Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult diseases, and we now have a better understanding of the molecular processes involved in genetic susceptibility and diseases mechanisms. The second edition fully incorporates these advances. The entire book has been updated and twelve new chapters have been added. Most of these chapters deal with diseases such as gallstones, osteoporosis, osteoarthritis, skin cancer, other common skin diseases, prostate cancer and migraine headaches that are seen by all physicians. Others address the genetic and molecular basis of spondylarthropathies, lupus, hemochromatosis, IgA deficiency, mental retardation, hearing loss, and the role of mitochondrial variation in adult diseases. Chapters on the evolution of human genetic disease and on animal models add important background on the omplexities of these diseases. Unique clinical applications of genetics to common diseases are covered in the additional new chapters on genetic counseling, pharmacogenetics, and the genetic consequences of modern therapeutics.

Table of Contents

Contributors	p. ix
Approaches
Approach to Genetic Basis of Common Diseases	p. 3
Molecular Genetics of Common Disease	p. 18
Genetic Epidemiologic Methods	p. 39
Evolution of Human Genetic Diseases	p. 50
Animal Models of Complex Genetic Disease	p. 65
Genetic Counseling: History, Risk Assessment, Strategies, and Ethical Considerations	p. 87
Cardiopulmonary Diseases
Genetics of Coronary Atherosclerosis	p. 105
Hypertension	p. 127
Chronic Obstructive Pulmonary Disease	p. 155
Immunologic and Infectious Diseases
Genetics of Human Susceptibility to Infectious Diseases: Progress and Prospects	p. 181
Genetics of Asthma and Bronchial Hyperresponsiveness	p. 198
IgA Deficiency and Common Variable Immunodeficiency	p. 210
Gastrointestinal Disorders
Peptic Ulcer and Gastritis	p. 229
Lactase Deficiency: Biological and Medical Aspects of the Adult Human Lactase Polymorphism	p. 250
Inflammatory Bowel Disease	p. 266
Gallstones	p. 298
Chronic Liver Disease	p. 336
Hereditary Hemochromatosis	p. 366
Gluten-Sensitive Enteropathy	p. 382
Endocrine Disorders
Thyroid Disease	p. 397
Type 1 Diabetes Mellitus	p. 431
Type 2 Diabetes Mellitus	p. 457
Obesity	p. 481
Genetics of Osteoporosis	p. 510
Hyperuricemia and Gout	p. 518
Genitourinary Disorders
Gynecologic Disorders	p. 539
Infertility and Pregnancy Loss	p. 554
Rheumatologic Diseases
Immunology and Immunogenetics	p. 573
Rheumatoid Arthritis	p. 587
Seronegative Spondyloarthropathies	p. 604
Genetics of Systemic Lupus Erythematosus	p. 612
Genetic Basis of Primary Osteoarthritis	p. 629
Common Disorders of Connective Tissue	p. 638
Cancer
Gastrointestinal Cancer	p. 649
Breast Cancer	p. 670
Familial and Genetic Influences on Risk of Lung Cancer	p. 700
Reproductive Organ Cancers	p. 713
Skin Cancer	p. 724
Prostate Cancer	p. 738
Hematologic Cancer	p. 749
Neuropsychiatric Disorders
Epilepsy	p. 779
Multiple Sclerosis	p. 805
Alzheimer's Disease	p. 818
Affective Disorders	p. 831
Schizophrenia	p. 850
Alcoholism	p. 876
Mental Retardation	p. 914
Hereditary Hearing Loss	p. 920
Migraine	p. 935
Other Common Problems
Common Skin Diseases	p. 951
Genetic Modulation of Aging and Longevity	p. 964
Mitochondrial Defects in Common Diseases	p. 975
Constitutional Chromosome Disorders in Adults	p. 989
Therapy
Genetic Consequences of Modern Therapeutics: Iatrogenic Mutagenesis	p. 1023
Pharmacogenetics, Ecogenetics, and Pharmacogenomics	p. 1033
Index	p. 1041
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