The Genetic Basis of Common Diseases

by King, Richard A.; Rotter, Jerome I.; Motulsky, Arno G.

• ISBN13: 9780195054828
• ISBN10: 0195054822
• Format: Hardcover
• Copyright: 1992-12-10
• Publisher: Oxford University Press

Summary

Here is a unique and comprehensive resource for human geneticists and physicians concerned with the genetic causes of diseases routinely seen in research, clinical practice, and genetic counseling. Each of the chapters covers a particular disease, describes the genetic factors involved, and define the relevant biochemical, immunological, and physiological markers. The expert, widely known contributors also detail clinical applications, with advice on how the genetic data can be used to evaluate individuals and families, interpret diagnostic texts, and manage the disease.

Table of Contents

Contributors	p. ix
Approaches
Approach to Genetic Basis of Common Diseases	p. 3
Molecular Genetics of Common Disease	p. 18
Genetic Epidemiologic Methods	p. 39
Evolution of Human Genetic Diseases	p. 50
Animal Models of Complex Genetic Disease	p. 65
Genetic Counseling: History, Risk Assessment, Strategies, and Ethical Considerations	p. 87
Cardiopulmonary Diseases
Genetics of Coronary Atherosclerosis	p. 105
Hypertension	p. 127
Chronic Obstructive Pulmonary Disease	p. 155
Immunologic and Infectious Diseases
Genetics of Human Susceptibility to Infectious Diseases: Progress and Prospects	p. 181
Genetics of Asthma and Bronchial Hyperresponsiveness	p. 198
IgA Deficiency and Common Variable Immunodeficiency	p. 210
Gastrointestinal Disorders
Peptic Ulcer and Gastritis	p. 229
Lactase Deficiency: Biological and Medical Aspects of the Adult Human Lactase Polymorphism	p. 250
Inflammatory Bowel Disease	p. 266
Gallstones	p. 298
Chronic Liver Disease	p. 336
Hereditary Hemochromatosis	p. 366
Gluten-Sensitive Enteropathy	p. 382
Endocrine Disorders
Thyroid Disease	p. 397
Type 1 Diabetes Mellitus	p. 431
Type 2 Diabetes Mellitus	p. 457
Obesity	p. 481
Genetics of Osteoporosis	p. 510
Hyperuricemia and Gout	p. 518
Genitourinary Disorders
Gynecologic Disorders	p. 539
Infertility and Pregnancy Loss	p. 554
Rheumatologic Diseases
Immunology and Immunogenetics	p. 573
Rheumatoid Arthritis	p. 587
Seronegative Spondyloarthropathies	p. 604
Genetics of Systemic Lupus Erythematosus	p. 612
Genetic Basis of Primary Osteoarthritis	p. 629
Common Disorders of Connective Tissue	p. 638
Cancer
Gastrointestinal Cancer	p. 649
Breast Cancer	p. 670
Familial and Genetic Influences on Risk of Lung Cancer	p. 700
Reproductive Organ Cancers	p. 713
Skin Cancer	p. 724
Prostate Cancer	p. 738
Hematologic Cancer	p. 749
Neuropsychiatric Disorders
Epilepsy	p. 779
Multiple Sclerosis	p. 805
Alzheimer's Disease	p. 818
Affective Disorders	p. 831
Schizophrenia	p. 850
Alcoholism	p. 876
Mental Retardation	p. 914
Hereditary Hearing Loss	p. 920
Migraine	p. 935
Other Common Problems
Common Skin Diseases	p. 951
Genetic Modulation of Aging and Longevity	p. 964
Mitochondrial Defects in Common Diseases	p. 975
Constitutional Chromosome Disorders in Adults	p. 989
Therapy
Genetic Consequences of Modern Therapeutics: Iatrogenic Mutagenesis	p. 1023
Pharmacogenetics, Ecogenetics, and Pharmacogenomics	p. 1033
Index	p. 1041
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