Genetic Predisposition to Cancer

by Eeles, Rosalind A.; Easton, Douglas F.; Ponder, Bruce A. J.; Eng, Charis

• ISBN13: 9780340762547
• ISBN10: 0340762543
• Edition: 2nd
• Format: Hardcover
• Copyright: 2004-10-28
• Publisher: Hodder Education Publishers

Summary

This book examines the principles underlying genetic predisposition to cancer in order to familiarise practising oncologists, geneticists and other professionals interested in cancer with this new and expanded field. The coverage is comprehensive, taking the reader from an introduction to genetic predisposition, through a discussion of the molecular biology and statistical techniques involved in the detection and cloning of predisposition genes to a consideration of familial cancer syndromes, encompassing rare and common cancers. The text also includes a discussion of genetic screening and cancer management options, and a consideration of the associated ethical and psychological issues. To reflect the rapid advances in the field since the first edition, the contents have been thoroughly updated with new chapters on the biological basis of cancer predisposition, population-based studies of susceptibility, Von-Hippel-Lindau syndrome and evaluation of management strategies for individuals at increased cancer risk.

Table of Contents

Contributors	vii
Foreword	xi
Sir Walter Bodmer
Foreword	xiii
Henry T. Lynch
Preface	xv
Acknowledgements	xvii
Glossary	xix
PART 1 BASIC PRINCIPLES
Genetic predisposition to cancer: an introduction	3	(8)
D. Timothy Bishop
Biological basis of cancer predisposition	11	(10)
Yves-Jean Bignon
From families to chromosomes: genetic linkage and association studies for finding cancer-predisposition genes	21	(20)
Douglas F. Easton
From chromosomes to genes: how to isolate cancer-predisposition genes	41	(7)
Richard Wooster
Screening for mutations in cancer-predisposition genes	48	(15)
Jan Vijg
Yousin Suh
PART 2 INHERITED CANCER SYNDROMES
Retinoblastoma: the paradigm for a genetically inherited cancer syndrome	63	(10)
Christopher Mitchell
Neurofibromatosis types 1 and 2	73	(24)
Susan M. Huson
Aurelia Norton
Multiple endocrine neoplasia type 1	97	(8)
Teresa Rudkin
William D. Foulkes
Multiple endocrine neoplasia type 2	105	(14)
Charis Eng
Bruce A.J. Ponder
Wilms tumour and other childhood renal tumours	119	(13)
Kathryn Pritchard-Jones
Norman Breslow
Genetic susceptibility to renal cell carcinoma	132	(9)
Eamonn R. Maher
Berton Zbar
The Li-Fraumeni syndrome and the role of TP53 mutations in predisposition to cancer	141	(14)
Jillian M. Birch
Cowden syndrome	155	(14)
Charis Eng
PART 3 CHROMOSOME FRAGILITY SYNDROMES AND THE GORLIN SYNDROME
Clinical, cellular and mutational variations in ataxia telangiectasia	169	(11)
A. Malcolm R. Taylor
Grant Stewart
Tatjana Stankovic
Somai Man
Philip J. Byrd
Fanconi anaemia	180	(13)
Pia A.J. Huber
Christopher G. Mathew
The Gorlin (nevoid basal cell carcinoma) syndrome	193	(21)
Peter A. Farndon
Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy: sun sensitivity, DNA repair defects and skin cancer	214	(21)
Colin F. Arlett
Alan R. Lehmann
PART 4 THE COMMON CANCERS
Genetics and the common cancers	235	(13)
Richard S. Houlston
Julian Peto
Familial breast cancer	248	(8)
Asher Y. Salmon
Rosalind A. Eeles
The BRCA1 and BRCA2 genes	256	(21)
Deborah Thompson
Douglas F. Easton
Screening for breast cancer in high-risk populations	277	(9)
Sue Moss
Risk-reducing mastectomy	286	(10)
Timothy I. Davidson
Nigel P.M. Sacks
The role of chemoprevention in breast cancer	296	(7)
Paul J. Ross
Trevor J. Powles
Familial ovarian cancer: genetics and management	303	(12)
Paul D.P. Pharoah
Bruce A.J. Ponder
Familial colon cancer syndromes and their genetics	315	(16)
Susan M. Farrington
Malcolm G. Dunlop
Screening and management of familial colon cancer	331	(8)
Shirley V. Hodgson
Victoria Murday
Familial prostate cancer and its management	339	(13)
Rashmi Singh
Rosalind A. Eeles
Lisa Cannon-Albright
William Isaacs
Familial melanoma and its management	352	(8)
Alisa M. Goldstein
Margaret A. Tucker
Familial predisposition to lung cancer	360	(8)
Thomas A. Sellers
Gloria M. Petersen
Ping Yang
Genetic susceptibility to carcinoma of the head and neck, stomach, and pancreas	368	(23)
William D. Foulkes
Elsa Lanke
Sarah Jefferies
Pierre O. Chappuis
PART 5 PSYCHOSOCIAL, ETHICAL AND ORGANISATIONAL ISSUES
The cancer family clinic	391	(13)
Rosalind A. Eeles
Victoria A. Murday
Psychological issues in cancer genetics	404	(10)
Kathryn M. Kash
Mary Kay Dabney
Susan K. Boolbol
The ethics of testing for cancer-predisposition genes	414	(11)
D. Gareth R. Evans
Patrick J. Morrison
Index	425