The Genetics of Complex Thyroid Diseases

by Akamizu, T.; Kasuga, M.; Davies, Terry F.

• ISBN13: 9784431703259
• ISBN10: 443170325X
• Format: Hardcover
• Copyright: 2002-02-01
• Publisher: Springer Verlag

Summary

The autoimmune thyroid diseases and familial thyroid cancers are the current target of molecular thyroid genetics. Unlike the situation in monogenic thyroid diseases, for which the molecular genetics has largely been clarified over the past 20 years, a methodological approach to these more complex forms of thyroid disease has not yet been well established. The determination of susceptibility genes, for example, remains a major challenge. The contributors to this volume are attempting to meet that challenge in research on molecular genetics. Meeting at the first International Symposium on the Genetics of Complex Thyroid Diseases, held in Kyoto, Japan, 20 distinguished researchers from five countries in addition to Japan shared their latest results and engaged in intense discussion, focusing on the autoimmune thyroid diseases and familial thyroid cancers. Their papers collected here are a valuable contribution to the field of the genetics of complex thyroid diseases.

Table of Contents

Preface	v
Organization of Symposium	vi
Acknowledgments	viii
Contributors	xi
Part 1 Autoimmune Thyroid Diseases
Genetic dissection of familial autoimmune thyroid diseases using whole genome screening	3	(20)
Y. Tomer
Genome screening for Graves' disease susceptibility loci in U.K. families	23	(19)
B. Vaidya
H. Imrie
P. Kendall-Taylor
S.H.S. Pearce
The involvement of the HLA region in genetic susceptibility to Graves' disease	42	(13)
J.M. Heward
HLA and autoimmune thyroid diseases	55	(9)
K. Yamamoto
T. Sasazuki
What can we learn from the genetics of diabetes?	64	(17)
D.W. Bowden
The genomic biology of the human chromosome 2q33 costimulatory receptor region	81	(22)
V. Ling
G.J. Fisk
CTLA-4 gene in the pathogenesis of Graves' disease	103	(5)
T. Yanagawa
T. Kouki
L.J. DeGroot
The evolving role of CTLA-4 in the genetic predisposition to AITD	108	(15)
G. Barbesino
Association of AITD with microsatellite markers for TSHR and CTLA-4 in Japanese patients	123	(16)
T. Akamizu
Part 2 Familial Thyroid Cancers
Familial non medullary thyroid cancer	139	(12)
O.H. Clark
Cowden disease and the PTEN/MMAC1 gene	151	(25)
B. McIver
N.L. Eberhardt
Molecular mechanisms of RET activation in human neoplasia	176	(8)
M. Santoro
F. Carlomagno
R.M. Melillo
G. Vecchio
A. Fusco
Lessons from Chernobyl; need for molecular epidemiology of childhood thyroid cancer	184	(14)
S. Yamashita
H. Namba
N. Takamura
K. Ashizawa
Y. Shibata
Genetic events in radiation-induced thyroid cancer	198	(22)
Y. E. Nikiforov
Key Word Index	220