The Genetics of Male Fertility

by Carrell, Douglas T.

• ISBN13: 9781588298638
• ISBN10: 1588298639
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-11-30
• Publisher: Humana Pr Inc

Summary

Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms. Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

Table of Contents

Preface	v
Contributors	xi
Part I: Methods and Tools for the Study of the Genetics of Male Infertility
1 The Genetics of Male Infertility in the Era of Genomics: Tools for Progress	3
Douglas T. Carrell
2 The Use of cDNA Libraries to Demonstrate a Linkage Between Transcription and Translation in Male Germ Cells	29
Norman B. Hecht
3 Considerations When Using Array Technologies for Male Factor Assessment	37
Adrian E. Platts, David J. Dix, and Stephen A. Krawetz
4 Microarray Analysis of a Large Number of Single-Nucleotide Polymorphisms in Individual Human Spermatozoa	55
Honghua Li, Xiangfeng Cui, Danielle M. Greenawalt, Guohong Hu, Nyam-Osor Chimge, Sreemanta Pramanik, Minjie Luo, Hui-Yun Wang, Irina V. Tereshchenko, Marco A. Azaro, Yong Lin, Qifeng Yang, James Y. Li, Yi Chu, Zhenwu Lin, Richeng Gao, Li Shen, Christina J. DeCoste, and Weichung J. Shih
5 Physiological and Proteomic Approaches to Understanding Human Sperm Function: Prefertilization Events	77
Sarah J. Conner, Linda Lefièvre, Jackson Kirkman-Brown, Gisela S.M. Machado-Oliveira, Frank Michelangeli, Stephen J. Publicover, and Christopher L.R. Barratt
6 Genetics of Idiopathic Male Infertility: The Power of a Cross-Species Approach	99
Angshumoy Roy, Yi-Nan Lin, and Martin M. Matzuk
Part II: Meiosis and Errors of Meiosis
7 The Immunocytogenetics of Human Male Meiosis: A Progress Report	115
Daniel Topping, Petrice Brown, and Terry Hassold
8 The Clinical Relevance of Sperm Aneuploidy	129
Renee H. Martin
9 DNA Repair Genes and Genomic Instability in Severe Male Factor Infertility	145
Francesca K.E. Gordon and Dolores J. Lamb
Part III: The Y Chromosome, Development, Spermatogenesis, and Sperm Maturation
10 Germ Cell-Specific Genes and Posttranscriptional Regulation in the Testis	167
Mark S. Fox and Renee A. Reijo Pera
11 The Genetics of Cryptorchidism	185
Alexander I. Agoulnik and Shu Feng
12 The Chromatoid Body and microRNA Pathways in Male Germ Cells	199
Martti Parvinen, Noora Kotaja, Durga Prasad Mishra, and Paolo Sassone-Corsi
13 Sperm Maturation in the Epididymis: Role of Segment-Specific Microenvironments	211
Gail A. Cornwall and Hans H. von Horsten
Part IV: Clinical Applications of the Study of the Genetics of Male Infertility
14 The Structure of the Y Chromosome in Infertility	233
Leslie Ayensu-Coker, Collin Bishop and Jan Rohozinski
15 Y Chromosome Microdeletions and Haplotypes	239
Ken McElreavey, Celia Ravel, Brahim El Houate, Jacqueline Mandelbaum, Sandra Chantot-Bastaraud, and Jean-Pierre Siffroi
16 The Genetics of Male Infertility: From Bench to Clinic	251
David M. de Kretser, Moira K. O'Bryan, Michael Lynch, Anne Reilly, Claire Kennedy, David Cram, and Robert I. McLachlan
17 The Future of the Diagnosis of Male (In)Fertility	267
Christopher De Jonge
18 Polymorphisms and Male Infertility	275
Csilla Krausz
19 The Genetics of Abnormal Protamine Expression	291
Vincent W. Aoki and Douglas T. Carrell
20 Chromatin Damage and Male Infertility	303
Denny Sakkas, Davide Bizzaro, and Gian C. Manicardi
21 Clinical Evaluation of the Genetics of Male Infertility	317
Peter N. Schlegel
Index	329