Genomes

by Sussman, Hillary E.; Smit, Maria A.

• ISBN13: 9780879698065
• ISBN10: 0879698063
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-03-24
• Publisher: Cold Spring Harbor Laboratory Press

Summary

Hundreds of genomes have been completely sequenced in the past decade, significantly advancing our understanding of genome structure and function. Genomescomprises a collection of review articles reprinted from the 10th Anniversary issue of the journal Genome Researchthat capture the status of genomic research in a selection of model species#x14;from microbes to human. Written by leaders in the field, each chapter focuses on a kingdom, group, or species and offers a unique perspective on the history, the current status, and future of genomics research. Topics addressed include gene regulatory networks in the fruit fly and the sea squirt, fungal genome evolution, mouse and rat mutagenesis, the future of crop plant genomics, how livestock genomics informs human medicine, the importance of the dog genome in studying human disease, and the search for #x1C;humanness#x1D; through human and chimp genome comparison. In addition, updates on emerging technologies in DNA sequencing and in gene prediction, as well as direction to relevant public resources, are given. This book serves as a valuable reference and teaching tool for established scientists in the genomics field and as a comprehensive overview for those with more general interests in biology.

Table of Contents

Preface,	vii
Foreword	ix
James D. Watson
1 Insights on Biology and Evolution from Microbial Genome Sequencing,	1	(18)
C.M. Fraser-Liggett
2 Changing Perspectives in Yeast Research Nearly a Decade after the Genome Sequence,	19	(22)
K Dolinski and D. Botstein
3 Genomics of the Fungal Kingdom: Insights into Eukaryotic Biology,	41	(30)
I.E. Galagan, M.R. Henn, L.-J. Ma, C.A. Cuomo, and B. Birren
4 The Arabidopsis Genome: A Foundation for Plant Research,	71	(26)
M. Bevan and S. Walsh
5 Grains of Knowledge: Genomics of Model Cereals,	97	(20)
A.H. Paterson, M. Freeling, and T Sasaki
6 Genomics in Caenorhabditis elegans: So Many Genes, Such a Little Worm,	117	(26)
L.W. Hillier, A. Coulson, J.I. Murray, Z. Bao, J.E. Sulston, and R.H. Waterston
7 Drosophila melanogaster: A Case Study of a Model Genomic Sequence and Its Consequences,	143	(16)
M. Ashburner and C.M. Bergman
8 Unraveling Genomic Regulatory Networks in the Simple Chordate, Ciona intestinalis,	159	(18)
Shi, M. Levine, and B. Davidson
9 Fish Genomics and Biology,	177	(22)
H. Roest Crollius and J. Weissenbach
10 Xenomics,	199	(22)
E. Amaya
11 Chicken Genome: Current Status and Future Opportunities,	221	(16)
D.W. Burt
12 Advances in Livestock Genomics: Opening the Barn Door,	237	(18)
J.E. Womack
13 The Canine Genome,	255	(26)
E.A. Ostrander and R.K. Wayne
14 Impact of Genomics on Research in the Rat,	281	(32)
J. Lazar, C. Moreno, H.J. Jacob, and A.E. Kwitek
15 The Mouse Genome,	313	(32)
J.L. Guénet
16 Genomics of the Future: Identification of Quantitative Trait Loci in the Mouse,	345	(12)
L. Flaherty, B. Herron, and D. Symula
17 Comparing the Human and Chimpanzee Genomes: Searching for Needles in a Haystack,	357	(38)
A. Varki and T.K. Altheide
18 Structure and Function of the Human Genome,	395	(18)
P.F.R. Little
19 Emerging Technologies in DNA Sequencing,	413	(26)
M.L. Metzker
20 Genome Annotation Past, Present, and Future: How to Define an Open Reading Frame at Each Locus,	439	(26)
M.R. Brent
Index,	465