Genomic Imprinting

by Reik, Wolf; Surani, Azim

• ISBN13: 9780199636259
• ISBN10: 0199636257
• Format: Paperback
• Copyright: 1997-12-04
• Publisher: IRL Press

Summary

Genomic imprinting, the differential marking of genes inherited from paternal and maternal sources, has been recognized since the late 1970s and is known to be involved in several inherited diseases. However, it is only very recently that questions surrounding the mechanisms of genomicimprinting have begun to be answered. This volume reviews the latest exciting developments, with full citations of all of the key bibliography. It also discusses the major unanswered questions in this field and outlines directions for future research. Topics covered in Genomic Imprinting include:the role of DNA methylation in mammalian development; developmental regulation of imprinting by DNA methylation; imprinting at the mouse and human IGF2R loci; function and epigenetic modification of the imprinted H19 gene; the imprinted insulin-like growth factor 2 gene; consequences of genomicimprinting for fetal development; genomic imprinting in the mouse; systematic approaches for the identification of imprinted genes; genomic imprinting as a developmental process disturbed in cancer; imprinting in the PraderWilli/Angelman syndrome region on human chromosome 15; convergent themes in Xchromosome inactivation and autosomal imprinting; and evolutionary theories of genomic imprinting.

Table of Contents

Role of DNA methylation in mammalian development

Developmental regulation of imprinting by DNA methylation

Imprinting at the mouse and human IGF2R loci

Function and epigenetic modification of the imprinted H19 gene

The imprinted insulin-like growth factor 2 gene

Consequences of genemoic imprinting for fetal development

Genomic imprinting in the mouse: possible final analysis

Systematic approaches for the identification of imprinted genes

Genomic imprinting as a developmental process disturbed in cancer

Imprinting in the Prader-Willi/Angelman syndrome region on human chromosome 15

Convergent themes in X chromosome inactivation and autosomal imprinting

Evolutionary theories of genomic imprinting

Table of Contents provided by Publisher. All Rights Reserved.