Goodman and Gilman's the Pharmacological Basis of Therapeutics

by Goodman, Louis Sanford; Hardman, Joel G.; Limbird, Lee E.

• ISBN13: 9780071124324
• ISBN10: 0071124322
• Edition: 10th
• Format: Hardcover
• Copyright: 2001-06-01
• Publisher: McGraw-Hill

Summary

*More than 106,000 copies sold of the previous edition*The definitive reference in pharmacology worldwide for physicians and medical students, pharmacists, and pharmacy students*Includes basic principles, all drug classes, and clinical chapters*New edition covers the latest developments in molecular pharmacology and clinical developments on the newest agents*Highlights include information on 150 new FDA-approved drugs, new chapters on alcohol, anti-HIV drugs, and a significant revision of all chaptersVisit http://www.goodmanandgilman.com for more information.

Table of Contents

Contributors	xv
Consultants to the Editors	xxi
Preface	xxv
Preface to the First Edition	xxvii
SECTION I GENERAL PRINCIPLES	1	(112)
Introduction	1	(2)
Alfred Goodman Gilman
Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination	3	(28)
Grant R. Wilkinson
Pharmacodynamics: Mechanisms of Drug Action and the Relationship Between Drug Concentration and Effect	31	(14)
Elliott M. Ross
Terry P. Kenakin
Principles of Therapeutics	45	(22)
Alan S. Nies
Principles of Toxicology and Treatment of Poisoning	67	(14)
Curtis D. Klaassen
Gene Therapy	81	(32)
Christopher S. Rogers
Bruce A. Sullenger
Alfred L. George, Jr.
SECTION II DRUGS ACTING AT SYNAPTIC AND NEUROEFFECTOR JUNCTIONAL SITES	113	(178)
Neurotransmission: The Autonomic and Somatic Motor Nervous Systems	115	(40)
Brian B. Hoffman
Palmer Taylor
Muscarinic Receptor Agonists and Antagonists	155	(20)
Joan Heller Brown
Palmer Taylor
Anticholinesterase Agents	175	(18)
Palmer Taylor
Agents Acting at the Neuromuscular Junction and Autonomic Ganglia	193	(22)
Palmer Taylor
Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists	215	(54)
Brian B. Hoffman
5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists	269	(22)
Elaine Sanders-Bush
Steven E. Mayer
SECTION III DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM	291	(352)
Neurotransmission and the Central Nervous System	293	(28)
Floyd E. Bloom
History and Principles of Anesthesiology	321	(16)
Charles Beattie
General Anesthetics	337	(30)
Alex S. Evers
C. Michael Crowder
Local Anesthetics	367	(18)
William A. Catterall
Kenneth Mackie
Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium	385	(14)
Eric J. Moody
Brett A. Simon
Roger A. Johns
Hypnotics and Sedatives	399	(30)
Dennis S. Charney
S. John Mihic
R. Adron Harris
Ethanol	429	(18)
Michael F. Fleming
S. John Mihic
R. Adron Harris
Drugs and the Treatment of Psychiatric Disorders: Depression and Anxiety Disorders	447	(38)
Ross J. Baldessarini
Drugs and the Treatment of Psychiatric Disorders: Psychosis and Mania	485	(36)
Ross J. Baldessarini
Frank I. Tarazi
Drugs Effective in the Therapy of the Epilepsies	521	(28)
James O. McNamara
Treatment of Central Nervous System Degenerative Disorders	549	(20)
David G. Standaert
Anne B. Young
Opioid Analgesics	569	(52)
Howard B. Gutstein
Huda Akil
Drug Addiction and Drug Abuse	621	(22)
Charles P. O'Brien
SECTION IV AUTACOIDS; DRUG THERAPY OF INFLAMMATION	643	(112)
Introduction	643	(2)
Jason D. Morrow
L. Jackson Roberts, II
Histamine, Bradykinin, and Their Antagonists	645	(24)
Nancy J. Brown
L. Jackson Roberts, II
Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor	669	(18)
Jason D. Morrow
L. Jackson Roberts, II
Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout	687	(46)
L. Jackson Roberts, II
Jason D. Morrow
Drugs Used in the Treatment of Asthma	733	(22)
Bradley J. Undem
Lawrence M. Lichtenstein
SECTION V DRUGS AFFECTING RENAL AND CARDIOVASCULAR FUNCTION	755	(248)
Diuretics	757	(32)
Edwin K. Jackson
Vasopressin and Other Agents Affecting the Renal Conservation of Water	789	(20)
Edwin K. Jackson
Renin and Angiotensin	809	(34)
Edwin K. Jackson
Drugs Used for the Treatment of Myocardial Ischemia	843	(28)
David M. Kerins
Rose Marie Robertson
David Robertson
Antihypertensive Agents and the Drug Therapy of Hypertension	871	(30)
John A. Oates
Nancy J. Brown
Pharmacological Treatment of Heart Failure	901	(32)
Henry Ooi
Wilson Colucci
Antiarrhythmic Drugs	933	(38)
Dan M. Roden
Drug Therapy for Hypercholesterolemia and Dyslipidemia	971	(32)
Robert W. Mahley
Thomas P. Bersot
SECTION VI DRUGS AFFECTING GASTROINTESTINAL FUNCTION	1003	(56)
Agents Used for Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastroesophageal Reflux Disease	1005	(16)
Willemijntje A. Hoogerwerf
Pankaj J. Pasricha
Prokinetic Agents, Antiemetics, and Agents Used in Irritable Bowel Syndrome	1021	(16)
Pankaj J. Pasricha
Agents Used for Diarrhea, Constipation, and Inflammatory Bowel Disease; Agents Used for Biliary and Pancreatic Disease	1037	(22)
Syed Jafri
Pankaj J. Pasricha
SECTION VII CHEMOTHERAPY OF PARASITIC INFECTIONS	1059	(82)
Introduction	1059	(10)
James W. Tracy
Leslie T. Webster, Jr.
Drugs Used in the Chemotherapy of Protozoal Infections: Malaria	1069	(28)
James W. Tracy
Leslie T. Webster, Jr.
Drugs Used in the Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections	1097	(24)
James W. Tracy
Leslie T. Webster, Jr.
Drugs Used in the Chemotherapy of Helminthiasis	1121	(20)
James W. Tracy
Leslie T. Webster, Jr.
SECTION VIII CHEMOTHERAPY OF MICROBIAL DISEASES	1141	(240)
Antimicrobial Agents: General Considerations	1143	(28)
Henry F. Chambers
Antimicrobial Agents: Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections	1171	(18)
William A. Petri, Jr.
Antimicrobial Agents: Penicillins, Cephalosporins, and Other β-Lactam Antibiotics	1189	(30)
William A. Petri, Jr.
Antimicrobial Agents: The Aminoglycosides	1219	(20)
Henry F. Chambers
Antimicrobial Agents: Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents	1239	(34)
Henry F. Chambers
Antimicrobial Agents: Drugs Used in the Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy	1273	(22)
William A. Petri, Jr.
Antimicrobial Agents: Antifungal Agents	1295	(18)
John E. Bennett
Antimicrobial Agents: Antiviral Agents (Nonretroviral)	1313	(36)
Frederick G. Hayden
Antimicrobial Agents: Antiretroviral Agents	1349	(32)
Stephen P. Raffanti
David W. Haas
SECTION IX CHEMOTHERAPY OF NEOPLASTIC DISEASES	1381	(80)
Introduction	1381	(8)
Paul Calabresi
Bruce A. Chabner
Antineoplastic Agents	1389	(72)
Bruce A. Chabner
David P. Ryan
Luis Paz-Ares
Rocio Garcia-Carbonero
Paul Calabresi
SECTION X DRUGS USED FOR IMMUNOMODULATION	1461	(24)
Immunomodulators: Immunosuppressive Agents, Tolerogens, and Immunostimulants	1463	(22)
Alan M. Krensky
Terry B. Strom
Jeffrey A. Bluestone
SECTION XI DRUGS ACTING ON THE BLOOD AND THE BLOOD-FORMING ORGANS	1485	(54)
Hematopoietic Agents: Growth Factors, Minerals, and Vitamins	1487	(32)
Robert S. Hillman
Anticoagulant, Thrombolytic, and Antiplatelet Drugs	1519	(20)
Philip W. Majerus
Douglas M. Tollefsen
SECTION XII HORMONES AND HORMONE ANTAGONISTS	1539	(206)
Pituitary Hormones and Their Hypothalamic Releasing Factors	1541	(22)
Keith L. Parker
Bernard P. Schimmer
Thyroid and Antithyroid Drugs	1563	(34)
Alan P. Farwell
Lewis E. Braverman
Estrogens and Progestins	1597	(38)
David S. Loose-Mitchell
George M. Stancel
Androgens	1635	(14)
Peter J. Snyder
Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones	1649	(30)
Bernard P. Schimmer
Keith L. Parker
Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas	1679	(36)
Stephen N. Davis
Daryl K. Granner
Agents Affecting Calcification and Bone Turnover: Calcium, Phosphate, Parathyroid Hormone, Vitamin D, Calcitonin, and Other Compounds	1715	(30)
Robert Marcus
SECTION XIII THE VITAMINS	1745	(48)
Introduction	1745	(8)
Robert Marcus
Ann M. Coulston
Water-Soluble Vitamins: The Vitamin B Complex and Ascorbic Acid	1753	(20)
Robert Marcus
Ann M. Coulston
Fat-Soluble Vitamins: Vitamins A, K, and E	1773	(20)
Robert Marcus
Ann M. Coulston
SECTION XIV DERMATOLOGY	1793	(26)
Dermatological Pharmacology	1795	(24)
Eric L. Wyatt
Steven H. Sutter
Lynn A. Drake
SECTION XV OPHTHALMOLOGY	1819	(30)
Ocular Pharmacology	1821	(28)
Sayoko E. Moroi
Paul R. Lichter
SECTION XVI TOXICOLOGY	1849	(176)
Heavy Metals and Heavy-Metal Antagonists	1851	(26)
Curtis D. Klaassen
Nonmetallic Environmental Toxicants: Air Pollutants, Solvents and Vapors, and Pesticides	1877	(148)
Curtis D. Klaassen
APPENDICES
I. Principles of Prescription Order Writing and Patient Compliance	1903	(14)
Lauralea Edwards
Dan M. Roden
II. Design and Optimization of Dosage Regimens: Pharmacokinetic Data	1917	(108)
Kenneth E. Thummel
Danny D. Shen
Index	2025