Growth Hormone in Adults: Physiological and Clinical Aspects

by Edited by Anders Juul , Jens O. L. Jorgensen

• ISBN13: 9780521641883
• ISBN10: 0521641888
• Edition: 2nd
• Format: Hardcover
• Copyright: 2000-06-12
• Publisher: Cambridge University Press

Summary

This revised edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the disorders that result from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject, and this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and its role in ageing and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. The volume is the most authoritative, comprehensive and detailed account available and will be an essential source of reference for all endocrinologists.

Table of Contents

List of contributors	ix
Preface	xv
Foreword	xvii
Niels E. Skakkebaek
Part I Introduction
Physiological regulators of growth hormone secretion	3	(51)
Mark L. Hartman
Insulin-like growth factors (IGF) and IGF-binding proteins: their use for diagnosis of growth hormone deficiency	54	(33)
Werner F. Blum
Growth hormone and IGF-I effects on in vivo substrate metabolism in humans	87	(17)
Niels Møller
Determination of growth hormone (GH) and GH binding proteins in serum	104	(21)
Sanne Fisker
Hans Ørskov
Part II Diagnostic and Clinical aspects
The syndrome of growth hormone deficiency in adults	125	(28)
Ross C. Cuneo
Franco Salomon
Peter H. Sonksen
The diagnosis of growth hormone deficiency in adults	153	(20)
David M. Hoffman
Ken K. Y. Ho
Monitoring growth hormone replacement therapy	173	(18)
Andrew A. Toogood
Simon J. Howell
Stephen M. Shalet
Part III Growth hormone replacement therapy in adults with growth hormone deficiency
The effect of growth hormone on protein metabolism	191	(13)
David L. Russell-Jones
Margot Umpleby
Growth hormone deficiency, insulin resistance and glucose metabolism	204	(18)
F. L. Hew
M. C. Christopher
F. P. Alford
Growth hormone and body composition	222	(11)
Jens Sandahl Christiansen
Nina Vahl
Effects of growth hormone on human fluid homeostasis	233	(18)
Jens Møller
Growth hormone and cardiac function	251	(14)
Antonio Cittadini
Salvatore Longobardi
Serafino Fazio
Luigi Sacca
Growth hormone and cardiovascular risk factors	265	(16)
Thord Rosen
Growth hormone (GH), exercise performance, muscle strength and sweat production in healthy subjects and in adults with GH deficiency	281	(20)
Anders Juul
Katharina Main
Niels E. Skakkebaek
Growth hormone and bone and mineral metabolism	301	(32)
Jean-Marc Kaufman
Mark Vandeweghe
Growth hormone and thyroid function and energy expenditure	333	(16)
Jens Otto Lunde Jørgensen
Troels Wolthers
Jørgen Weeke
Growth hormone and psychosocial and central nervous effects	349	(24)
Jan-Ove Johansson
Lena Wiren
Bengt-Ake Bengtsson
Impact of gender and age on growth hormone responsiveness	373	(26)
Pia Burman
Gudmundur Johannsson
Part IV Growth hormone, growth-hormone releasing peptides and ageing
Growth hormone and ageing	399	(42)
Kieran G. O'Connor
Marc R. Blackman
Growth hormone releasing substances - basic aspects	441	(22)
Karen Kulju McKee
Andrew D. Howard
Scott D. Feighner
Sheng-Shung Pong
Roy G. Smith
Clinical uses of growth hormone releasing peptides (GHRPs) and GHRP analogues in adults	463	(22)
Ian M. Chapman
Michael O. Thorner
Index	485