Handbook of Basic Pharmacokinetics

by Ritschel, Wolfgang

• ISBN13: 9781582120546
• ISBN10: 1582120544
• Edition: 6th
• Format: Hardcover
• Copyright: 2004-05-17
• Publisher: APhA Publications

Summary

The sixth edition of the classic pharmacokinetics handbook remains a user-friendly consolidation of principles and techniques for practitioners, researchers, and students involved in the various applications of pharmacokinetics. Readers will find the book current, accurate, comprehensive, and useful clinically.

Author Biography

Gregory L. Kearns is Marion Merrell, Dow/Missouri Chair in Pediatric Pharmacology and Professor of Pediatrics and Pharmacology at the University of Missouri-Kansas City. He is also Chief Division of Pediatric Pharmacology and Medical Toxicology and Director, Pediatric Pharmacology Research Unit, at Children's Mercy Hospitals and Clinics in Kansas City, Missouri.

Table of Contents

Preface	p. ix
Definitions and Glossary	p. 1
The LADMER System--Liberation, Absorption, Distribution, Metabolism, Elimination, and Response	p. 10
Organs, Tissues, Cells, and Organelles	p. 13
Cell Membranes	p. 20
Drug-Receptor Interactions	p. 27
Absorption/Transport Mechanisms	p. 31
pK[subscript a] and Degree of Ionization	p. 47
Lipid/Water Partition Coefficient	p. 53
Physicochemical Factors Altering Biological Performance of Drugs	p. 57
Biopharmaceutical Data of the Gastrointestinal Tract	p. 66
Fluid Compartments and Circulatory System	p. 79
Binding of Drugs to Biological Material	p. 88
Drug Biotransformation	p. 98
Compartment Models	p. 115
Determination of Rate Constants	p. 122
Volume of Distribution and Distribution Coefficient	p. 131
Excretion and Clearance of Drugs	p. 139
Urinary and Biliary Recycling	p. 165
Cumulative Urinary Excretion	p. 167
Area Under the Blood Level-Time Curve	p. 179
Pharmacokinetics of Single Dose Administration	p. 188
Pharmacokinetics of Multiple Dosing	p. 200
Compartment Model Independent Analysis	p. 220
Pediatric Pharmacokinetics	p. 227
Drug Dosage in Elderly Patients	p. 241
Drug Dosage in Obese Patients	p. 250
Drug Disposition in Pregnancy	p. 255
Dosage Regimen Design	p. 260
Drug Monitoring and Dose Adjustment	p. 278
Physiological and Pathological Factors Influencing Drug Response	p. 281
First Dose Size in Man	p. 288
Forensic Pharmacokinetics	p. 291
Nonlinear Pharmacokinetics	p. 295
Curve Fitting	p. 302
Correlation of Clinical Response with Drug Disposition	p. 311
Bioavailability and Bioequivalence	p. 318
Body Surface Areas	p. 339
Extracorporeal Methods of Drug Removal	p. 342
Pharmacogenetics and Pharmacogenomics	p. 355
Appendix	p. 367
Index	p. 403
Table of Contents provided by Rittenhouse. All Rights Reserved.