Handbook of Biophotonics

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  • Edition: 1st
  • Format: eBook
  • Copyright: 2013-01-14
  • Publisher: Wiley-VCH

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Author Biography

Jurgen Popp holds a full Professor at the Friedrich-Schiller-University Jena. He is Director of the Institute of Physical Chemistry at the university as well as Director of the Institute of Physical High Technology (IPHT) Jena. In the German Main Research Topic 'Biophotonik' (National Network financed by the BMBF) he serves as the speaker.

Associate Editors:
Arthur Chiou (National Yang-Ming University, Taipei, Taiwan)
Valery V. Tuchin (Saratov State University, Russia)
Stefan Heinemann (Friedrich-Schiller-University Jena, Germany)

Table of Contents

I. Preface
1.Definition and general introduction into Biophotonics
2. Worldwide research activities in Biophotonics
II. Photonics
1. Short introduction into atomic or molecular configuration
2. Fundamentals of linear and non-linear light matter interactions
2.1. Linear light matter interaction
2.1.1 Light scattering and polarisation
2.1.2 Linear Absorption
2.1.3 Spontaneous Emission (fluorescence etc.)
2.1.4 Reflexion, refraction, diffraction etc.
2.2. Non-linear light matter interactio
2.2.1 x(2)-processes (second harmonic, sum / difference frequency generation etc.)
2.2.2 x(3)-processes (third harmonic generation, two-photon absorption, CARS etc.)
2.3. Manipulating matter with light
3. Basics of optics/photonics and their instrumentation
4.Instruments of biotechnology and medicine
III. Biology
1. Short introduction into the building blocks of living cells and tissue
2. Fundamentals of biological processes
3. Molecular biological methods
4. Origin and formation of diseases

1. Laboratory Medicine
1.1. Analysis of body liquids (Allergology, Immunology, Hematology, Epidemology, Endocrinology etc.)
1.1.1. Hematopathology /
Lymphopathology Flow Cytometry Photothermal and photoacoustic flow cytometry Fluorescence Lifetime Flow Cytometer Spectral Analysis Cytometer
1.1.2. Microscopic and spectroscopic methods Sensing and Glucose Determination Using Fluorescent Probes
1.1.3. Bioassays /
Biochips Holey fiber and photonic crystal technologies
1.2. Medical microbiology
1.2.1. Dynamic light scattering studies of the effect of heat and disinfectants on health relevant spores and bacteria
1.3. Infectious diseases
1.3.1. Identification and characterization of Microorganisms by Vibrational Spectroscopy
2 Pathology
2.1.Surgical Pathology (Optical Biopsy Analysis)
2.1.1. Enabling technologies Cell sorting Laser Microtomy
2.1.2. Optical Biopsy technologies Classical Microscopy Telepathology Clinical Fluorescence Diagnostics Fluorescence spectroscopy In vitro instrumentation In vivo instrumentation. Fluorescent probes (Fluorescence Standards, Green Protein technology) Optical Coherence Tomography Diffuse optical imaging Optoacoustic imaging+ultrasound Diagnostics based on Vibrational Spectroscopic Techniques Raman microscopy CARS Microscopy IR microscopy
3. Oncology
3.1. Optical Therapies
3.1.1. Photodynamic Therapy Singlet oxygen in PDT Molecular targeting of photosensitizers Photodynamic molecular beacons Oxygen effects in PDT On-line treatment monitoring and control Organic LEDs for PDT Nanoparticles for PDT
3.1.2. Interoperative OCT monitoring
4. Cardiology, Angiology
4.1. Diagnostic Imaging
4.1.1. Intracoronary diagnostics
4.1.2. Microvascular blood flow: Microcirculation Imaging Laser Doppler Perfusion Imaging (LDPI) High resolution resonant Doppler spectral OCT Reflectance polarization spectroscopy Dynamic light scattering spectroscopy Laser Doppler blood flowmetry and self-mixing laser Doppler velocimetry Fiber-optic laser Doppler velocity profile sensor In vivo bidirectional color Doppler flow imaging using optical coherence tomography Speckle technologies in in vivo blood flow imaging
4.1.3. Optical oximetry
4.2. Photonic Therapies
4.2.1. Atrial fibrillation Fiber photo-catheters
4.2.2. Phlebology: Varicose Veins Therapy control, e.g. measuring contraction of vessels using OCT
5. Pulmonology
5.1. Bronchoscopy
5.1.1. Fluorescence Bronchoscopy
5.1.2. Laser Therapy
5.1.3. PDT
6. Urology and Nephrology
6.1. Bladder biopsy with OCT
6.2. Imaging and Minimally Invasive Therapy in Urology
6.2.1. Advanced endoscopy, laser therapy and laser surgery in Urology
7. Gastroenterology
7.1. Barrett's oesophagus and gastroesophageal reflux disease ? diagnosis and therapy
7.2. Hepatology
7.2.1. Liver Tumor Gross Margin Identification and Ablation Monitoring
8. Rheumatology
8.1. Diagnosis and monitoring of rheumatoid arthritis
8.1.1. Near-infrared fluorescence imaging
8.1.2. Fluorescence reflectance imaging
8.1.3. Diffuse optical tomography
8.1.4. Photoacoustic detection
8.1.5. Laser Doppler Imaging
9. Ophthalmology and Optometry
9.1. Ocular Diagnostics and Imaging
9.1.1. Glaucoma diagnosis (OCT)
9.1.2. Early diagnosis of age-related macular degeneration (OCT, Autofluorescence)
9.1.3. Early detection of cataracts
9.1.4. Monitoring retinal ischemia
9.2. Ocular therapy
9.2.1. Age-related macular degeneration PDT Transpupillary Thermotherapy Selective retina therapy
9.2.2. Glaucoma Therapy Antiglaucoma and ocular blood flow Treatment control by Laser scanning Tomography /
Polarimetry modulation of wound healing in glaucoma filtration surgery
10. Otolaryngology (ENT)
10.1. Diagnostics and Imaging
10.1.1. Tomography of the Human Oral Cavity and Oropharynx
11. Neurology
11.1. In-vivo Brain Imaging /
11.1.1. Vascular compartment analysis
11.1.2. Assessment of Infant Brain Development
11.1.3. Revealing the roles of prefrontal cortex in memory
11.1.4. Intra-operative characterization of gliomas
11.1.5. Cerebral blood flow and oxygenation
11.2. Therapy
11.2.1. Imaging and Treatment of Brain Tumors using Vascular Targeted Nanoparticles
12. Dermatology
12.1. Skin Diagnostics
12.1.1. Determination of skin photoaging
12.1.2. Determination of primary melanin deposits
12.1.3. Assessment of skin erythema and pigmentation
12.1.4. Monitoring of blood flow and Hemoglobin oxygenation
12.1.5. Glucose and other metabolites sensing in skin
12.1.6. Psoriasis, fungal infections and nevi
12.1.7. Diagnosis of skin tumors
12.1.8. Quantification of collagen and elastin
12.1.9. Skin and wound infections
12.2. Skin Therapy
12.2.1. Basal cell carcinoma and actinic keratose
12.2.2. Psoriasis and acne
12.2.3. Anti microbial PDT
12.2.4. Wound healing
12.2.5. Hemangioma and cutaneous lesions
12.2.6. Evaluation of transdermal processes (e.g. drug delivery)
13. Gynecology and Obstetrics
13.1. Diagnosis of neoplastic processes in the uterine cervix and vulva
13.2. Guided needle-biopsies of breast cancer
14. Reproductive Medicine
14.1. Diagnostics and Imaging
14.1.1. Sperm Retrieval in Azoospermic Men
14.2. Laser Manipulation and Therapy
14.2.1. Trapping and guiding of sperms
14.2.2. Laser thinning of the the zona pellucida
15. Genetics
15.1. Transfection of cardiac cells by means of laser-assisted optoporation
16. Regenerative Medicine (Tissue Engineering)
17. Laser surgery
17.1. Plastic Surgery
17.1.1. Laser Periodontal Plastic Surgery
17.1.2. Laser Skin Surgery
17.2. Vascular Surgery
17.2.1. Endovenous Laser Treatment (EVLT)
17.3. Neurosurgery
17.3.1. Laser treatment of cerebral ischemia
17.4. Eye surgery
17.4.1. Refractive surgery Laser Assisted In-Situ Keratomileusis Photorefractive keratectomy Laser Assisted Sub-Epithelium Keratomileusis EPI-LASIK
17.4.2. Glaucoma surgery Laser trabeculoplasty
17.4.3. Vitreo-retinal surgery Laser Photocoagulation
17.5. Otolaryngological sugery
17.5.1. Stenosis
17.5.2. Recurrent Respiratory papillomatosis
18. Dentistry
18.1. Diagnostic Imaging and Spectroscopy
18.1.1. Caries Detection NIR spectroscopy and OCT Fluorescence spectroscopy Fiber optic spectroscopy
18.1.2. Stress /
Crack detection
18.1.3. Periodontal disease
18.1.4. Pulp vitality of human teeth determined with Laser Doppler flowmetry
18.2. Therapeutic Methods, Dental Restoration, Prosthetics
18.2.1. Laser ablation of dental restorative materials
18.2.2. Laser ablation of dental enamel
18.2.3. Laser endodontic therapy

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