Handbook of Cancer Chemotherapy

by Skeel, Roland T.

• ISBN13: 9780781716178
• ISBN10: 0781716179
• Edition: 5th
• Format: Paperback
• Copyright: 1999-04-12
• Publisher: LWW

Summary

The Fifth Edition of this practical handbook is an up-to-date guide to all aspects of cancer chemotherapy. In an easy-to-follow outline format, the book provides complete coverage of the basic principles of rational chemotherapy, the drugs and biologic agents available, the treatment of specific cancers, and selected aspects of supportive care. The Fifth Edition features a greatly expanded chapter on high-dose chemotherapy with progenitor cell and cytokine support. Information has been added on the primary indications, usual dosage and schedule, and expected toxicities of the many new drugs and biologic agents that have recently become available, including rituximab and trastuzumab. All chapters on specific cancer sites have been thoroughly updated. The basic principles and supportive care sections have been streamlined to highlight the issues that are most essential in daily patient care. Appendices include American Cancer Society screening guidelines and a short list of Internet addresses for cancer information.

Table of Contents

Contributing Authors	ix
Preface	xiii
Section I. Basic Principles and Considerations of Rational Chemotherapy
Biologic and Pharmacologic Basis of Cancer Chemotherapy	3	(17)
Roland T. Skeel
Principles of Therapy with Biologic Response Modifiers and their Role in Cancer Management	20	(14)
David R. Parkinson
Systemic Assessment of the Patient with Cancer and Long Term Consequences of Treatment	34	(22)
Roland T. Skeel
Patricia A. Ganz
Selection of Treatment for the Patient with Cancer	56	(7)
Roland T. Skeel
Section II. Chemotherapeutic and Biotherapeutic Agents and Their Use
Antineoplastic Drugs and Biologic Response Modifiers: Classification, Use, and Toxicity of Clinically Useful Agents	63	(81)
Roland T. Skeel
High Dose Chemotherapy with Hematopoietic Progenitor Cell and Cytokine Support	144	(33)
David H. Vesole
Section III. Chemotherapy of Human Cancer
Carcinomas of the Head and Neck	177	(21)
Ronald C. DeConti
Carcinoma of the Lung	198	(16)
Joan H. Schiller
Carcinomas of the Gastrointestinal Tract	214	(24)
John C. Marsh
Carcionomas of the Pancreas, Liver, Gallbladder, and Bile Ducts	238	(14)
David J. Schifeling
Carcinoma of the Breast	252	(26)
Roland T. Skeel
Gynecologic Cancer	278	(36)
C. O. Granai
Walter H. Gajewski
Robert D. Legare
Urologic and Male Genital Cancers	314	(19)
Scott B. Saxman
Craig R. Nichols
Tyroid and Adrenal Carcinomas	333	(20)
Samir N. Khleif
Melanomas and Other Skin Malignancies	353	(19)
Larry Nathanson
Primary and Metastatic Brain Tumors	372	(10)
Jane B. Alavi
Soft Tissue Sarcomas	382	(11)
Robert S. Benjamin
Bone Sarcomas	393	(12)
Robert S. Benjamin
Acute Leukemias	405	(43)
Chatchada Karanes
Neil A. Lachant
Chronic Leukemias	448	(17)
Carol S. Palackdharry
Myelproliferative and Myelodysplastic Syndromes	465	(10)
Peter White
Carol S. Palackdharry
Hodgkin's Disease	475	(14)
Richard S. Stein
Non-Hodgkin's Lymphomas	489	(26)
Richard S. Stein
John P. Greer
Multiple Myeloma and Other Plasma Cell Disorders	515	(16)
Martin M. Oken
Metastatic Cancer of Unknown Origin	531	(8)
Martin M. Oken
HIV-Associated Malignancies	539	(16)
Lynne Jahnke
Jamie H. Von Roenn
Section IV. Selected Aspects of Supportive Care of Patients with Cancer
Side Effects of Cancer Chemotherapy	555	(19)
Janelle Tipton
Roland T. Skeel
Infections: Etiology, Treatment, and Prevention	574	(24)
Rodger D. MacArthur
Transfusion Therapy, Bleeding, and Clotting	598	(23)
Mary R. Smith
Nurjehan Khan
Oncology Emergencies and Critical Care Issues: Anaphylaxis, Spinal Cord Compression, Cerebral Edema, Superior Vena Cava Syndrome, Hypercalcemia, Tumor Lysis Syndrome, and Respiratory Failure	621	(21)
Salvatore Veltri
Malignant Pleural, Peritoneal, and Pericardial Effusions and Meningeal Infiltrates	642	(14)
Walter D.Y. Quan
Cancer Pain	656	(23)
Charles S. Cleeland
Eduardo D. Bruera
Emotional and Psychiatric Problems in Patients with Cancer	679	(22)
Kathy S.N. Franco-Bronson
Kristi S. Williams
Appendices
A. Nomogram for Determining Body Surface Area of Adults from Height and Mass	695	(1)
B. Nomogram for Determining Body Surface Area of Children from Height and Mass	696	(1)
C. American Cancer Society Cancer Screening Guidelines	697	(2)
D. A Short List of Helpful Internet Addresses for Cancer Information	699	(2)
Subject Index	701