Handbook of Developmental Neurotoxicology

by Slikker, Jr.; Chang

• ISBN13: 9780126488609
• ISBN10: 0126488606
• Format: Hardcover
• Copyright: 1998-07-08
• Publisher: Elsevier Science

Summary

The Handbook of Developmental Neurotoxicology provides a comprehensive account of the impacts, mechanisms, and clinical relevances of chemicals on the development of the nervous system. The book is written by internationally recognized experts on developmental neurotoxicology, covering subjects from basic neuro-development to toxic syndromes induced by various chemicals. It is an important text for both students and professionals who are interested in developmental neurobiology and neurotoxicology. Key Features * Written by internationally recognized experts on developmental neurotoxicology * Includes extensive references * Well illustrated with diagrams, charts and tables * Provides coverage of basic neurobiology as well as neurotoxicology

Table of Contents

Contributors	xi	(4)
Foreword	xv	(2)
Preface	xvii
Part I Cellular and Molecular Morphogenesis of the Nervous System	1	(116)
AN INTRODUCTORY OVERVIEW	1	(2)
Louis W. Chang
1 BRAIN MORPHOGENESIS AND DEVELOPMENTAL NEUROTOXICOLOGY	3	(40)
Karl F. Jensen
Susan M. Catalano
2 CADHERIN CELL ADHESION MOLECULES IN NORMAL AND ABNORMAL NEURAL DEVELOPMENT	43	(18)
Gerald B. Grunwald
3 NEURITE DEVELOPMENT	61	(26)
Gerald Audesirk
Teresa Audesirk
4 MYELINATION, DYSMYELINATION, AND DEMYELINATION	87	(30)
G. Jean Harry
Arrel D. Toews
Part II Developmental Biology/Toxicology	117	(106)
AN INTRODUCTORY OVERVIEW	117	(2)
Thomas Sadler
5 SIGNAL TRANSDUCTION PATHWAYS AS TARGETS FOR INDUCED EMBRYOTOXICITY	119	(22)
Robert M. Greene
Paul Nugent
M. Michele Pisano
Wayde Weston
Merle Potchinsky
6 TROPHIC NERVE GROWTH FACTORS	141	(12)
Haeyoung Kong
Patrizia Casaccia-Bonnefil
Moses V. Chao
7 NEUROTOXIC AND NEUROTROPHIC EFFECTS OF GABAergic AGENTS ON DEVELOPING NEUROTRANSMITTER SYSTEMS	153	(6)
Jean M. Lauder
Jiangping Liu
8 APOPTOSIS	159	(30)
Margaret A. Shield
Philip E. Mirkes
9 PERIODS OF SUSCEPTIBILITY TO INDUCED MALFORMATIONS OF THE DEVELOPING MAMMALIAN BRAIN	189	(20)
Gregory D. Bennett
Richard H. Finnell
10 TRANSGENIC ANIMAL MODELS: FUNCTIONAL ANALYSIS OF DEVELOPMENTAL TOXICITY AS ILLUSTRATED WITH THE p53 SUPPRESSOR MODEL	209	(14)
Thomas B. Knudsen
Judith A. Wubah
Part III Synaptogenesis and Neurotransmission	223	(82)
AN INTRODUCTORY OVERVIEW	223	(2)
Tomas R. Guilarte
11 NEURAL CREST CELL MIGRATION	225	(20)
Andrew G. Hendrickx
Pamela E. Peterson
12 ONTOGENY OF NEUROTRANSMITTERS: MONOAMINES	245	(12)
Harry W. Broening
William Slikker, Jr.
13 CENTRAL CHOLINERGIC NEUROBIOLOGY	257	(18)
David A. Jett
14 ONTOGENY OF SECOND MESSENGER SYSTEMS	275	(10)
Lucio G. Costa
15 THE N-METHYL-D-ASPARTATE RECEPTOR: PHYSIOLOGY AND NEUROTOXICOLOGY IN THE DEVELOPING BRAIN	285	(20)
Tomas R. Guilarte
Part IV Nutrient and Chemical Disposition	305	(96)
AN INTRODUCTORY OVERVIEW	305	(2)
William Slikker, Jr.
16 PB/PK MODELS	307	(14)
Ellen J. O'Flaherty
17 DEVELOPMENTAL ENZYMOLOGY: XENOBIOTIC BIOTRANSFORMATION	321	(18)
Mont R. Juchau
Hao Chen
18 BLOOD-BRAIN BARRIER: PHYSIOLOGICAL AND FUNCTIONAL CONSIDERATIONS	339	(14)
Michael Aschner
19 ANTIOXIDANT ENZYMES: DEVELOPMENTAL PROFILES AND THEIR ROLE IN METAL-INDUCED OXIDATIVE STRESS	353	(18)
Saber Hussain
Syed F. Ali
20 FOOD AND NUTRIENT EXPOSURE THROUGHOUT THE LIFE SPAN: HOW DOES WHAT WE EAT TRANSLATE INTO EXPOSURE, DEFICIENCIES, AND TOXICITIES?	371	(12)
Margaret L. Bogle
21 DRUG AND CHEMICAL CONTAMINANTS IN BREAST MILK: EFFECTS ON NEURODEVELOPMENT OF THE NURSING INFANT	383	(18)
Janine E. Polifka
Part V Behavioral Assessment	401	(36)
AN INTRODUCTORY OVERVIEW	401	(2)
Jerrold S. Meyer
22 BEHAVIORAL ASSESSMENT IN DEVELOPMENTAL NEUROTOXICOLOGY: APPROACHES INVOLVING UNCONDITIONED BEHAVIORS AND PHARMACOLOGIC CHALLENGES IN RODENTS	403	(24)
Jerrold S. Meyer
23 ASSESSMENT OF BEHAVIOR IN PRIMATES	427	(10)
Merle G. Paule
Part VI Clinical Assessment and Epidemiology	437	(68)
AN INTRODUCTORY OVERVIEW	437	(2)
J. M. Friedman
24 EVALUATION OF THE HUMAN NEWBORN INFANT	439	(16)
Anneloes van Baar
25 DEVELOPMENTAL EVALUATION OF THE OLDER INFANT AND CHILD	455	(14)
Claire D. Coles
Julie A. Kable
26 BEHAVIORAL EVALUATION OF THE OLDER INFANT AND CHILD	469	(18)
Peter A. Fried
27 EPIDEMIOLOGIC STUDIES OF THE EFFECTS OF PRENATAL COCAINE EXPOSURE ON CHILD DEVELOPMENT AND BEHAVIOR	487	(10)
Gale A. Richardson
Nancy L. Day
28 ASSESSMENT OF CASE REPORTS AND CLINICAL SERIES	497	(8)
J. M. Friedman
Part VII Specific Neurotoxic Syndromes	505	(168)
AN INTRODUCTORY OVERVIEW	505	(2)
Louis W. Chang
29 FETAL MINAMATA DISEASE: CONGENITAL METHYLMERCURY POISONING	507	(10)
Louis W. Chang
Grace Liejun Guo
30 DEVELOPMENTAL NEUROTOXICITY OF CADMIUM	517	(22)
Lloyd Hastings
Marian L. Miller
31 DEVELOPMENTAL LEAD EXPOSURE: NEUROBEHAVIORAL CONSEQUENCES	539	(20)
Deborah C. Rice
32 DEVELOPMENTAL TOXICITY OF PESTICIDES	559	(8)
Durisala Desaiah
33 THE EFFECTS OF ALCOHOL ON THE FETAL BRAIN: THE CENTRAL NERVOUS SYSTEM TRAGEDY	567	(20)
Irena Nulman
Bonnie O'Hayon
Jonathan Gladstone
Gideon Koren
34 DEVELOPMENTAL NEUROTOXICITY OF NICOTINE	587	(30)
Edward D. Levin
Theodore A. Slotkin
35 MATERNAL DRUG ABUSE AND ADVERSE EFFECTS ON NEUROBEHAVIOR OF OFFSPRING	617	(14)
Merle G. Paule
36 THE NEUROBEHAVIORAL TERATOLOGY OF VITAMIN A ANALOGS	631	(12)
Jane Adams
R. Robert Holson
37 DEVELOPMENTAL NEUROTOXICITY OF ANTIEPILEPTIC DRUGS	643	(18)
Deborah K. Hansen
R. Robert Holson
38 NEUROTERATOLOGY OF AUTISM	661	(12)
Patricia M. Rodier
Part VIII Risk Assessment	673	(60)
AN INTRODUCTORY OVERVIEW	673	(2)
William Slikker, Jr.
39 CURRENT APPROACHES TO RISK ASSESSMENT FOR DEVELOPMENTAL NEUROTOXICITY	675	(12)
Carole A. Kimmel
40 ANIMAL/HUMAN CONCORDANCE	687	(22)
James L. Schardein
41 PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS IN THE RISK ASSESSMENT OF DEVELOPMENTAL NEUROTOXICANTS	709	(18)
Kannan Krishnan
Melvin Andersen
42 QUANTITATIVE MODELS OF RISK ASSESSMENT FOR DEVELOPMENTAL NEUROTOXICANTS	727	(6)
William Slikker, Jr.
David W. Gaylor
Index	733