Handbook of Dystonia, Second Edition

by Stacy; Mark A.

• ISBN13: 9781841848518
• ISBN10: 1841848514
• Format: Hardcover
• Copyright: 2012-05-28
• Publisher: CRC Press

Summary

As many as 250,000 people in the United States have dystonia, making it the third most common movement disorder following essential tremor and Parkinson's disease. This authoritative reader-friendly resource provides a wide-ranging overview of the latest research and developments regarding the pathogenesis, evaluation, and management of the disease. Providing detailed coverage of every available treatment option for dystonia including four categorized sections on medical management, botulinum toxin injections, phenol or neurolytic therapy, and surgical intervention, this source summarizes what is known about the disorder and dramatically improves the recognition and understanding of this debilitating disease.

Author Biography

Mark A. Stacy is Professor of Neurology, and vice Dean of Clinical Research at Duke University Medical Center in Durham, North Carolina. Professor Stacy graduated with a MD degreefrom-the University of Missouri, Columbia and completed his neurology residency at Hahnemann University in Philadelphia, Pennsylvania; before completing his Fellowship in Movement Disorders at Baylor College of Medicine. He is a member ok many organizations including the American Academy of Neurology the American Neurological Association and Movement Disorders Society, where he serves as co-editor of the society newsletter, Moving Along.

Table of Contents

Contributors	p. x
Preface	p. xiv
List of Abbreviations	p. xvi
Epidemiology and Pathogenesis
Introduction to dystonia	p. 1
Epidemiology of dystonia	p. 11
Genetic evaluation in hereditary dystonia	p. 22
Functional anatomy of the basal ganglia	p. 53
Physiology of primary dystonia	p. 65
Pathology of the dystonias	p. 74
Neuroimaging in dystonia	p. 101
Signs and Symptoms
Evaluation and management of the primary dystonia patient	p. 114
Cranial dystonia	p. 127
Cervical dystonia	p. 144
Limb dystonia	p. 159
Spasmodic dysphonia	p. 176
Embouchure and other task-specific musician's dystonias	p. 187
Sports-related task-specific dystonia: The yips	p. 212
Dopa-responsive dystonia	p. 221
Rapid-onset dystonia-parkinsonism: More than just dystonia	p. 241
Secondary dystonia	p. 251
Dystonic symptoms associated with parkinsonian disorders	p. 276
Drug-induced dystonia	p. 297
Psychogenic dystonia	p. 307
Nonmotor symptoms in dystonia	p. 320
Spasticity	p. 339
Treatment Options
Medical therapy for dystonia	p. 357
Anatomic principles for botulinum toxin injection	p. 374
Botulinum toxin: From molecule to clinic	p. 399
Botulinum toxins in the treatment of dystonia	p. 413
OnabotulinumtoxinA: BOTOX®	p. 436
RimabotulinumtoxinB	p. 452
Dysport (abobotulinumtoxinA) botulinum toxin type A	p. 463
Xeomin incobotulinumtoxinA	p. 469
Phenal neurolysis in the treatment of dystonia	p. 476
Selective denervation in cervical dystonia	p. 489
Repetitive transcranial magnetic stimulation in the treatment of dystonia	p. 501
Brain surgery for dystonia	p. 512
Index	p. 531
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